Graduate studies at Western
Theoretical Medicine and Bioethics 27 (2):149-167 (2006)
|Abstract||A probabilistic explication is offered of equipoise and uncertainty in clinical trials. In order to be useful in the justification of clinical trials, equipoise has to be interpreted in terms of overlapping probability distributions of possible treatment outcomes, rather than point estimates representing expectation values. Uncertainty about treatment outcomes is shown to be a necessary but insufficient condition for the ethical defensibility of clinical trials. Additional requirements are proposed for the nature of that uncertainty. The indecisiveness of our criteria for cautious decision-making under uncertainty creates the leeway that makes clinical trials defensible.|
|Keywords||cautiousness clinical decision-making clinical trials equipoise uncertainty|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
S. D. Halpern, J. H. Karlawish & Charles Weijer, Informing Patients of Uncertainty in Clinical Trials.
Lynn A. Jansen (2005). A Closer Look at the Bad Deal Trial: Beyond Clinical Equipoise. Hastings Center Report 35 (5):29-36.
Malcolm G. Booth (2007). Informed Consent in Emergency Research: A Contradiction in Terms. Science and Engineering Ethics 13 (3):351-359.
Marek Czarkowski (2006). The Protection of Patients' Rights in Clinical Trials. Science and Engineering Ethics 12 (1):131-138.
Margaret B. Liu (2010). A Clinical Trials Manual From the Duke Clinical Research Institute: Lessons From a Horse Named Jim. Wiley-Blackwell.
Danielle Laudy (2009). End of Life Pediatric Research: What About the Ethics? [REVIEW] Journal of Academic Ethics 7 (1-2):87-91.
Maurie Markman (2004). The Research Misconception. International Journal of Applied Philosophy 18 (2):241-252.
L. B. McCullough (2012). Responsibly Managing Uncertainties In Clinical Ethics. Journal of Medicine and Philosophy 37 (1):1-5.
Franklin G. Miller & Howard Brody (2002). What Makes Placebo-Controlled Trials Unethical? American Journal of Bioethics 2 (2):3 – 9.
Benjamin Djulbegovic (2007). Articulating and Responding to Uncertainties in Clinical Research. Journal of Medicine and Philosophy 32 (2):79 – 98.
Added to index2009-01-28
Total downloads9 ( #122,430 of 729,710 )
Recent downloads (6 months)1 ( #61,087 of 729,710 )
How can I increase my downloads?