The Overlap Feature of the Genetic Equidistance Result—A Fundamental Biological Phenomenon Overlooked for Nearly Half of a Century

Biological Theory 5 (1):40-52 (2010)
The genetic equidistance result shows that different species are approximately equidistant to a simpler outgroup in protein sequence similarity, as first reported by Margoliash in 1963. This result, together with those of Zuckerkandl and Pauling in 1962 inspired the molecular clock and in turn the neutral theory of evolution. Here it is shown that the clock/neutral theory had from the beginning overlooked another characteristic of the equidistance result, the overlap feature, which shows a large number of overlapped mutant amino acid positions where any pair of any three species is different provided that the species concerned differ from one another in complexity as a result of macroevolution. In contrast, when simple organisms of similar complexity and short evolutionary divergence are compared, there are only a small number of overlaps largely consistent with chance or the neutral theory. The full reality of the equidistance result strongly supports the Maximum Genetic Diversity hypothesis, a more complete account of hereditary changes
Keywords No keywords specified (fix it)
Categories (categorize this paper)
DOI 10.1162/BIOT_a_00021
 Save to my reading list
Follow the author(s)
My bibliography
Export citation
Find it on Scholar
Edit this record
Mark as duplicate
Revision history Request removal from index
Download options
PhilPapers Archive

Upload a copy of this paper     Check publisher's policy on self-archival     Papers currently archived: 15,938
External links
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library
References found in this work BETA

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles
Henry Howe & John Lyne (1992). Gene Talk in Sociobiology. Social Epistemology 6 (2):109 – 163.
Joseph Agassi (1980). Between Science and Technology. Philosophy of Science 47 (1):82-99.
Lenny Moss (1992). A Kernel of Truth? On the Reality of the Genetic Program. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1992:335 - 348.
Johannes Roessler (2011). Perceptual Attention and the Space of Reasons. In Christopher Mole, Declan Smithies & Wayne Wu (eds.), Attention: Philosophical and Psychological Essays. Oxford University Press 274.
Fritz Allhoff (2004). Telomeres and the Ethics of Human Cloning. American Journal of Bioethics 4 (2):29 – 31.

Monthly downloads

Added to index


Total downloads

41 ( #80,805 of 1,725,630 )

Recent downloads (6 months)

3 ( #211,030 of 1,725,630 )

How can I increase my downloads?

My notes
Sign in to use this feature

Start a new thread
There  are no threads in this forum
Nothing in this forum yet.