Central excitation and inhibitory mechanisms and neuroplasticity are also manifested in trigeminal nociceptive pathways

Behavioral and Brain Sciences 20 (3):453-454 (1997)
Central sensitization and related neurochemical mechanisms are also induced in V nociceptive pathways after craniofacial injury or inflammation. Their characteristics raise additional possibilities that may explain some of the phenomena outlined by coderre & katz, dickenson, and wiesenfeld-hallin et al. They also underscore the need for therapeutic approaches to reduce nociceptive inputs to the CNS or their neuroplastic effects which can potentially enhance post-traumatic pain
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