David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Foundations of Chemistry 4 (2):97-125 (2002)
This paper investigates the interface between philosophy and biochemistry. While it is problematic to justify the application of a particular philosophical model to biochemistry, it seems to be even more difficult to develop a special “Philosophy for Biochemistry”. Alternatively, philosophy can be used in biochemistry based on an alternative approach that involves an interdependent iteration process at a philosophical and (bio)chemical level (“Exeter Method”). This useful iteration method supplements more abstract approaches at the interface between philosophy and natural sciences, and serves the biochemical community to systematically locate logical inconsistencies that arise from more theoretical aspects of the scientific process. Initial cycles of this iteration process identify the in vitro–in vivo problem as a central epistemological difficulty in biochemical research. While previous attempts have generated ad hoc rules to mend the gap between chemistry, biochemistry and biology in order to justify in vitro experimentation, this paper concludes that in vitro experimentation is heavily based on chemistry and cannot derive definite statements about biological processes. It can, however, generate results that will influence the direction of future biological research. The consequence is that the relationship between in vitro and in vivo experimentation is more of a psychological or social one than of a logical nature. Apart from highlighting these inconsistencies in biochemical thinking (“problem awareness”), the Exeter Method demands an improvement of biochemical terminology that contains separate and unequivocally defined terms for in vitro and in vivo systems.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
U. Deichmann (2002). Chemists and Biochemists During the National Socialist Era. Angewandte Chemie - International Edition 41 (8):1310-1328.
Ute Deichmann (2007). “Molecular” Versus “Colloidal”: Controversies in Biology and Biochemistry, 1900–1940. Bulletin for the History of Chemistry 32 (2):105-118.
Eduard Glas (1979). Chemistry and Physiology in Their Historical and Philosophical Relations. Delft University Press.
Andoni Ibarra & Thomas Mormann (2006). Scientific Theories as Intervening Representations. Theoria 55 (1):21 - 38.
William Bechtel (2007). In Search of Mitochondrial Mechanisms: Interfield Excursions Between Cell Biology and Biochemistry. Journal of the History of Biology 40 (1):1 - 33.
Joseph D. Robinson (1992). Aims and Achievements of the Reductionist Approach in Biochemistry/Molecular Biology/Cell Biology: A Response to Kincaid. Philosophy of Science 59 (3):465-470.
Roger Strand, Ragnar Fjelland & Torgeir Flatmark (1996). In Vivo Interpretation of in Vitro Effect Studies with a Detailed Analysis of the Method of in Vitro Transcription in Isolated Cell Nuclei. Acta Biotheoretica 44 (1).
Roger Strand (1999). Towards a Useful Philosophy of Biochemistry: Sketches and Examples. [REVIEW] Foundations of Chemistry 1 (3):269-292.
Added to index2009-01-28
Total downloads8 ( #182,336 of 1,140,270 )
Recent downloads (6 months)1 ( #142,694 of 1,140,270 )
How can I increase my downloads?