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- Colin Klein (2010). Philosophical Issues in Neuroimaging. Philosophy Compass 5 (2):186-198.Functional neuroimaging (NI) technologies like Positron Emission Tomography and functional Magnetic Resonance Imaging (fMRI) have revolutionized neuroscience, and provide crucial tools to link cognitive psychology and traditional neuroscientific models. A growing discipline of 'neurophilosophy' brings fMRI evidence to bear on traditional philosophical issues such as weakness of will, moral psychology, rational choice, social interaction, free will, and consciousness. NI has also attracted critical attention from psychologists and from philosophers of science. I review debates over the evidential status of fMRI, including the differences between brain scans and ordinary images, the legitimacy of forward inference and reverse inference, and deductive versus probabilistic accounts of NI evidence. I conclude with a discussion of fMRI as exploratory rather than confirmatory evidence, linking this debate to the growing literature on cognitive ontology.
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The method of positron emission tomography (PET imaging) illustrates the circular logic popular in subtractive neuroimaging and linear reductive cognitive psychology. Both require that strictly feed-forward, modular, cognitive components exist, before the fact, to justify the inference of particular components from images (or other observables) after the fact. Also, both require a "true" componential theory of cognition and laboratory tasks, before the fact, to guarantee reliable choices for subtractive contrasts. None of these possibilities are likely. Consequently, linear reductive analysis has failed to yield general, reliable, componential accounts.
Cognitive neuroscientists use functional magnetic resonance imaging (fMRI) to measure properties of a participant’s brain during a cognitive task. These imaging results are transformed into compelling pictures of brain activity using statistical models. I will argue that, for a broad class of experiments, neuroimaging experts have a tendency to over‐interpret the functional significance of their data. This over‐interpretation appears to follow from contentious theoretical assumptions about the mind‐brain connection, and from a propensity to conflate the anatomical location of a statistically‐significant correlation with knowledge of the mechanistic functioning at that location.
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Running head: Functional neuroimaging Abstract Several recently developed techniques enable the investigation of the neural basis of cognitive function in the human brain. Two of these, PET and fMRI, yield whole-brain images reflecting regional neural activity associated with the performance of specific tasks. This article explores the spatial and temporal capabilities and limitations of these techniques, and discusses technical, biological, and cognitive issues relevant to understanding the goals and methods of neuroimaging studies. The types of advances in understanding cognitive and brain function made possible with these methods are illustrated with examples from the neuroimaging literature.
Under the umbrella of the burgeoning neurotransdisciplines, scholars are using the principles and research methodologies of their primary and secondary fields to examine developments in neuroimaging, neuromodulation and psychopharmacology. The path for advanced scholarship at the intersection of law and neuroscience may clear if work across the disciplines is collected and reviewed and outstanding and debated issues are identified and clarified. In this article, I organize, examine and refine a narrow class of the burgeoning neurotransdiscipline scholarship; that is, scholarship at the interface of law and functional magnetic resonance imaging (fMRI).
Running head: Functional neuroimaging Abstract Several recently developed techniques enable the investigation of the neural basis of cognitive function in the human brain. Two of these, PET and fMRI, yield whole-brain images reflecting regional neural activity associated with the performance of specific tasks. This article explores the spatial and temporal capabilities and limitations of these techniques, and discusses technical, biological, and cognitive issues relevant to understanding the goals and methods of neuroimaging studies. The types of advances in understanding cognitive and brain function made possible with these methods are illustrated with examples from the neuroimaging literature.
Neuroscience has long had an impact on the field of psychiatry, and over the last two decades, with the advent of cognitive neuroscience and functional neuroimaging, that influence has been most pronounced. However, many question whether psychopathology can be understood by relying on neuroscience alone, and highlight some of the perceived limits to the way in which neuroscience informs psychiatry.
Psychiatry as Cognitive Neuroscience is a philosophical analysis of the role of neuroscience in the study of psychopathology. The book examines numerous cognitive neuroscientific methods, such as neuroimaging and the use of neuropsychological models, in the context of a variety of psychiatric disorders, including depression, schizophrenia, dependence syndrome, and personality disorders.
Psychiatry as Cognitive Neuroscience includes chapters on the nature of psychiatry as a science; the compatibility of the accounts of mental illness derived from neuroscience, information-processing, and folk psychology; the nature of mental illness; the impact of methods such as fMRI, neuropsychology, and neurochemistry, on psychiatry; the relationship between phenomenological accounts of mental illness and those provided by naturalistic explanations; the status of delusions and the continuity between delusions and ordinary beliefs; the interplay between clinical and empirical findings in psychopathology and issues in moral psychology and ethics.
With contributions from world class experts in philosophy and cognitive science, this book will be essential reading for those who have an interest in the importance and the limitations of cognitive neuroscience as an aid to understanding mental illness.
Functional magnetic resonance imaging (or fMRI)1 is widely used to support hypotheses about brain function. Many find the images produced from fMRI data to be especially compelling evidence for scientific hypotheses [McCabe and Castel, 2008]. There are many problems with all of this; I want to start with two of them, and argue that they get us closer to an under-appreciated worry about many imaging experiments.
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fMRI promises to uncover the functional structure of the brain. I argue, however, that pictures of ‘brain activity' associated with fMRI experiments are poor evidence for functional claims. These neuroimages present the results of null hypothesis significance tests performed on fMRI data. Significance tests alone cannot provide evidence about the functional structure of causally dense systems, including the brain. Instead, neuroimages should be seen as indicating regions where further data analysis is warranted. This additional analysis rarely involves simple significance testing, and so justified skepticism about neuroimages does not provide reason for skepticism about fMRI more generally.
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