Causal isolation robustness analysis: the combinatorial strategy of circadian clock research

Biology and Philosophy 26 (5):773-791 (2011)
Abstract
This paper distinguishes between causal isolation robustness analysis and independent determination robustness analysis and suggests that the triangulation of the results of different epistemic means or activities serves different functions in them. Circadian clock research is presented as a case of causal isolation robustness analysis: in this field researchers made use of the notion of robustness to isolate the assumed mechanism behind the circadian rhythm. However, in contrast to the earlier philosophical case studies on causal isolation robustness analysis (Weisberg and Reisman in Philos Sci 75:106–131, 2008 ; Kuorikoski et al. in Br J Philos Sci 61:541–567, 2010 ), robustness analysis in the circadian clock research did not remain in the level of mathematical modeling, but it combined it with experimentation on model organisms and a new type of model, a synthetic model
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References found in this work BETA
Paul Humphreys (2002). Computational Models. Proceedings of the Philosophy of Science Association 2002 (3):S1-S11.

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Citations of this work BETA
Sara Green (2013). When One Model is Not Enough: Combining Epistemic Tools in Systems Biology. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):170-180.
Tarja Knuuttila & Andrea Loettgers (2013). Basic Science Through Engineering? Synthetic Modeling and the Idea of Biology-Inspired Engineering. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):158-169.
Gry Oftedal & Veli-Pekka Parkkinen (2013). Synthetic Biology and Genetic Causation. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):208-216.
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