The role of basic science in evidence-based medicine

Biology and Philosophy 26 (1):81-98 (2011)
Abstract
Proponents of Evidence-based medicine (EBM) do not provide a clear role for basic science in therapeutic decision making. Of what they do say about basic science, most of it is negative. Basic science resides on the lower tiers of EBM's hierarchy of evidence. Therapeutic decisions, according to proponents of EBM, should be informed by evidence from randomised studies (and systematic reviews of randomised studies) rather than basic science. A framework of models explicates the links between the mechanisms of basic science, experimental inquiry, and observed data. Relying on the framework of models I show that basic science often plays a role not only in specifying experiments, but also analysing and interpreting the data that is provided. Further, and contradicting what is implied in EBM's hierarchy of evidence, appeals to basic science are often required to apply clinical research to therapeutic questions. © 2010 Springer Science+Business Media B.V
Keywords Evidence-based medicine   Epidemiology   Basic medical science   Clinical decisions   Randomised controlled trials
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References found in this work BETA
A. la Caze (2009). Evidence-Based Medicine Must Be .. Journal of Medicine and Philosophy 34 (5):509-527.
Adam La Caze (2008). Evidence-Based Medicine Can't Be…. Social Epistemology 22 (4):353 – 370.
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A. la Caze (2009). Evidence-Based Medicine Must Be .. Journal of Medicine and Philosophy 34 (5):509-527.
Adam La Caze (2008). Evidence-Based Medicine Can't Be…. Social Epistemology 22 (4):353 – 370.
Mona Gupta (2007). Does Evidence-Based Medicine Apply to Psychiatry? Theoretical Medicine and Bioethics 28 (2):103.
John Worrall (2010). Evidence: Philosophy of Science Meets Medicine. Journal of Evaluation in Clinical Practice 16 (2):356-362.
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