Tensegrity behaviour of cortical and cytosolic cytoskeletal components in twisted living adherent cells
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Valérie M. Laurent, Patrick Cañadas, Redouane Fodil, Emmanuelle Planus, Atef Asnacios, Sylvie Wendling & Daniel Isabey
Acta Biotheoretica 50 (4):331-356 (2002)
The present study is an attempt to relate the multicomponent response of the cytoskeleton (CSK), evaluated in twisted living adherent cells, to the heterogeneity of the cytoskeletal structure - evaluated both experimentally by means of 3D reconstructions, and theoretically considering the predictions given by two tensegrity models composed of (four and six) compressive elements and (respectively 12 and 24) tensile elements. Using magnetic twisting cytometry in which beads are attached to integrin receptors linked to the actin CSK of living adherent epithelial cells, we specifically measured the elastic CSK response at quasi equilibrium state and partitioned this response in terms of cortical and cytosolic contributions with a two-component model (i.e., a series of two Voigt bodies). These two CSK components were found to be prestressed and exhibited a stress-hardening response which both characterize tensegrity behaviour with however significant differences: compared to the cytosolic component, the cortical cytoskeleton appears to be a faster responding component, being a less prestressed and easily deformable structure. The discrepancies in elastic behaviour between the cortical and cytosolic CSK components may be understood on the basis of prestress tensegrity model predictions, given that the length and number of constitutive actin elements are taken into account.
|Keywords||Philosophy Philosophy of Biology Evolutionary Biology|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Stephen Grossberg (1997). Principles of Cortical Synchronization. Behavioral and Brain Sciences 20 (4):689-690.
Stuart Hameroff, Search for Quantum and Classical Modes of Information Processing in Microtubules: Implications for “the Living State”.
Alasdair I. Houston & John M. McNamara (2005). John Maynard Smith and the Importance of Consistency in Evolutionary Game Theory. Biology and Philosophy 20 (5):933-950.
Julian Chela-Flores (1992). Influence of Chromatin Molecular Changes on RNA Synthesis During Embryonic Development. Acta Biotheoretica 40 (1):41-49.
Luiz Carlos L. Silveira (2004). Parallel Visual Pathways From the Retina to the Visual Cortex – How Do They Fit? Behavioral and Brain Sciences 27 (1):50-51.
Zi-Qin Xu (1998). Ideas in Theoretical Biology Do MTS Have the Function of Message Transmission? Acta Biotheoretica 46 (1):85-87.
W. Tecumseh Fitch (2008). Nano-Intentionality: A Defense of Intrinsic Intentionality. Biology and Philosophy 23 (2):157-177.
Jürgen Bereiter-Hahn (1985). Architecture of Tissue Cells the Structural Basis Which Determines Shape and Locomotion of Cells. Acta Biotheoretica 34 (2-4):139-148.
Yves Burnod (1991). Organizational Levels of the Cerebral Cortex: An Integrated Model. Acta Biotheoretica 39 (3-4):351-361.
Added to index2009-01-28
Total downloads7 ( #304,000 of 1,726,249 )
Recent downloads (6 months)5 ( #147,227 of 1,726,249 )
How can I increase my downloads?