David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 40 (2-3):177-193 (1992)
In the present study, we have demonstrated hysteresis phenomena in the excitability of single, enzymatically dissociated guinea pig ventricular myocytes. Membrane potentials were recorded with patch pipettes in the whole-cell current clamp configuration. Repetitive stimulation with depolarizing current pulses of constant cycle length and duration but varying strength led to predictable excitation (1:l) and non-excitation (1:0) patterns depending on current strength. In addition, transition between patterns depended on the direction of current intensity change and stable hysteresis loops were obtained in stimulus:response pattern vs. current intensity plots in 14 cells. Increase of pulse duration and decrease of stimulation rate contributed to a reduction in hysteresis loop areas. Changes in amplitude and shape of the subthreshold responses during the transitions from one stable pattern to the other, suggested that activity led to an increase in membrane resistance, particularly in the voltage domain between resting potential, and threshold. Therefore, we modelled the dynamic behaviour of the single cells as a function of diastolic membrane resistance, using previously published analytical solutions. Numerical iteration of the analytical model equations closely reproduced the experimental hysteresis loops in both qualitative and quantitative ways. In particular, the effect of stimulation frequency on the model was similar to the experimental findings. The overall study suggests that the excitability pattern of guinea pig ventricular myocytes accounts for hysteresis and bistabilities when current intensity is allowed to fluctuate around threshold levels.
|Keywords||No keywords specified (fix it)|
No categories specified
(categorize this paper)
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Jon Elster (1976). A Note on Hysteresis in the Social Sciences. [REVIEW] Synthese 33 (1):371-391.
J.-P. Françoise & C. Piquet (2005). Hysteresis Dynamics, Bursting Oscillations and Evolution to Chaotic Regimes. Acta Biotheoretica 53 (4):381-392.
B. M. P. M. Oliveira (2010). Dynamics of Immunological Models. Acta Biotheoretica 58 (4):391-404.
J. Barkley Rosser & Robert W. Bond, Chaotic Hysteresis and Systemic Economic Transformation: Soviet Investment Patterns.
James H. Moor (1986). Computer-Assisted Instruction and the Guinea Pig Dilemma. Teaching Philosophy 9 (4):351-354.
Trudo Lemmens & Carl Elliott (2001). Justice for the Professional Guinea Pig. American Journal of Bioethics 1 (2):51-53.
Nancy M. P. King & Richard Robeson (2007). Athlete or Guinea Pig? Sports and Enhancement Research. Studies in Ethics, Law, and Technology 1 (1).
R. G. Seigneuric, J.-L. Chassé, P. Auger & A. Bardou (2005). Simulated Interactions Between a Class III Antiarrhythmic Drug and a Figure 8 Reentry. Acta Biotheoretica 53 (4):265-275.
Sorry, there are not enough data points to plot this chart.
Added to index2009-01-28
Recent downloads (6 months)0
How can I increase my downloads?