David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 33 (4):219-225 (1984)
Under the influence of recurrent deleterious mutation and selection, asexual and sexual populations reach a deterministic equilibrium with individuals carrying 0,1,2,. . . harmful mutations. When a favourable mutation (aA) occurs in an asexual population it will usually occur in an individual who has one or more (k) deleterious mutations. Muller's ratchet then applies as A will thereafter never occur in an individual with less than k mutations. If the selective advantage of A is less than the selective disadvantage of k harmful mutations then A will not spread. If it is greater it may spread carrying k deleterious mutations to fixation. Sexual populations are not affected in this way. A will spread through the population experiencing genomes with 0,1,2,. . . deleterious mutations in accordance with the deterministic equilibrium.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
I. Walker (1996). Prediction of Evolution? Somatic Plasticity as a Basic, Physiological Condition for the Viability of Genetic Mutations. Acta Biotheoretica 44 (2):165-168.
Steven W. Gangestad & Ronald A. Yeo (2006). Mutations, Developmental Instability, and the Red Queen. Behavioral and Brain Sciences 29 (4):412-413.
Hans Joachim Poethke (1988). Sex Ratio Polymorphism: The Impact of Mutation and Drift on Evolution. Acta Biotheoretica 37 (2):121-147.
Sahotra Sarkar (1990). On the Possibility of Directed Mutations in Bacteria: Statistical Analyses and Reductionist Strategies. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1990:111 - 124.
Masatoshi Nei (2007). The New Mutation Theory of Phenotypic Evolution. Proc Natl Acad Sci U S A 104 (30):12335-12242.
Michael Bölker (2004). Bear Ye One Another’s Genetic Burdens: The Price of Diversity and Complexity. Poiesis and Praxis 3 (1-2):73-82.
Michael Bölker (2004). Bear Ye One Another's Genetic Burdens: The Price of Diversity and Complexity. Poiesis and Praxis 3 (s 1-2):73-82.
J. T. Manning & D. P. E. Dickson (1986). Environmental Change, Mutational Load and the Advantage of Sexual Reproduction. Acta Biotheoretica 35 (3):149-162.
Armando Aranda-Anzaldo (2001). Cancer Development and Progression: A Non-Adaptive Process Driven by Genetic Drift. Acta Biotheoretica 49 (2):89-108.
Added to index2009-01-28
Total downloads7 ( #423,486 of 1,796,307 )
Recent downloads (6 months)2 ( #348,557 of 1,796,307 )
How can I increase my downloads?