David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 51 (4):245-263 (2003)
A simplified model using kinetic logic is proposed to approach the problem after Hepatitis B viral (HBV) infection. It accounts for several stable regimes or attractors corresponding to the essential dynamic behaviour of the replication of the Hepatitis B virus. Infection with the virus can result in viral clearance, fulminant hepatic failure and death, or chronic transmissible infection, that is multistationarity corresponding to the existence of the positive feedback circuit in our modelling. Another implication of this model is the existence of oscillations or homeostatic mechanisms, sometimes observed in the viral cycle, consistent with the existence of the negative feedback circuit. Thus, this report shows how a simple model of kinetic logic may be used to account for the variety of manifestations of HBV infection. This model implies the presence of the Hepatitis B e antigen, whose conservation suggests that it plays an important role in the life cycle of hepadnaviruses. Its function in the viral cycle is still unknown, but our model suggests that this antigen could explain the passage from one state of the viral infection (acute or latent) to another, as well as the oscillatory behavior which may account for the intermittent symptoms of hepatitis observed in some patients. Furthermore, this model shows a virgin state. This state is also reached after recovery. The model proposed demonstrates that starting from a viral acute infection, the host's immune response, depending on the immunological status of the patient, can lead to viral clearance, or to periodic spontaneous reactivation.
|Keywords||Philosophy Philosophy of Biology Evolutionary Biology|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Nancy Mueller (1986). The Epidemiology of the Human Immunodeficiency Virus Infection. Journal of Law, Medicine & Ethics 14 (5-6):250-258.
James J. Goedert (2002). New Challenges to Health: The Threat of Virus Infection (Review). Perspectives in Biology and Medicine 45 (2):300-302.
William C. Buhles (2011). Compassionate Use A Story of Ethics and Science in the Development of a New Drug. Perspectives in Biology and Medicine 54 (3):304-315.
Diana Barrigar, David Flagel & Ross Upshur (2001). Hepatitis B Virus Infected Physicians and Disclosure of Transmission Risks to Patients: A Critical Analysis. [REVIEW] BMC Medical Ethics 2 (1):1-10.
Timothy F. Murphy (1994). Health Care Workers with Hiv and a Patient's Right to Know. Journal of Medicine and Philosophy 19 (6):553-569.
R. Poll (2011). Managing the Public Health Risk of a 'Sex Worker' with Hepatitis B Infection: Legal and Ethical Considerations. Journal of Medical Ethics 37 (10):623-626.
E. M. (1999). The Prion Challenge to the `Central Dogma' of Molecular Biology, 1965-1991 - Part I: Prelude to Prions. Studies in History and Philosophy of Science Part C 30 (1):1-19.
Anne-France Viet, Christine Fourichon, Christine Jacob, Chantal Guihenneuc-Jouyaux & Henri Seegers (2006). Approach for Qualitative Validation Using Aggregated Data for a Stochastic Simulation Model of the Spread of the Bovine Viral-Diarrhoea Virus in a Dairy Cattle Herd. Acta Biotheoretica 54 (3):207-217.
David Shaw (2008). Dentistry and the Ethics of Infection. Journal of Medical Ethics 34 (3):184-187.
C. Martinet-Edelist (1999). Dynamical Behaviour of Viral Cycle and Identification of Steady States. Acta Biotheoretica 47 (3-4):267-280.
Added to index2009-01-28
Total downloads6 ( #302,951 of 1,699,588 )
Recent downloads (6 months)5 ( #128,702 of 1,699,588 )
How can I increase my downloads?