Online research in philosophy

Sydney Shoemaker, developing an idea of Wittgenstein’s, argues that we are immune to error through misidentification relative to the first-person pronoun. Although we might be liable to error when “I” (or its cognates) is used as an object, we are immune to error when “I” is used as a subject (as when one says, “I have a toothache”). Shoemaker claims that the relationship between “I” as-subject and the mental states of which it is introspectively aware is tautological: when, say, we judge that “I feel pain,” we are tautologically aware that feels pain is instantiated and that it is instantiated in oneself. Moreover, he contends that this relationship holds not just for bodily sensations, but also for the sense of agency and for visual perception. But we deny that this relationship is tautological; instead, we treat Shoemaker’s principle (IEM) as a hypothesis. We then proceed to show that certain pathological states and experimentally-induced illusions can be adduced to show that IEM describes not a necessary relationship but a contingent relationship, one that sometimes fails to obtain. That we are not immune to error in the way Shoemaker describes has grave consequences for many aspects of his ideas concerning the first-person perspective. In the course of arguing that these empirical phenomena count against IEM, we also show that not only can the content of conscious experience be misrepresented, so too can the subject: that is, not only can the what of conscious experience be misrepresented, so too can the who.

Applying and extending principles that can help prevent consumer error, worker fault, managerial mistakes, and organizational blunders, Human Error: Causes and Control provides useful information on theories, methods, and specific techniques for controlling human error. It forms a how-to manual of good practice, focusing on identifying human error, its causes, and how to control or prevent it. It presents constructs that assist in optimizing human performance and to achieve higher safety goals. Human Error: Causes and Control bridges the gap and illustrates the means for achieving a comprehensive, fully integrated, process compatible, user effective, methodologically sound model.

Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli influence the course of immune activation.

Upshot: The cognitive paradigm organizes immune phenomena with an eye towards understanding the immune system as a perceptive faculty, where examination of the basic regulation of unstimulated immune activity becomes the primary investigative focus. While a fecund research program organized around the hypothesized “autonomous network theory” has yielded important insight into the “conservative physiology of the immune system,” the theoretical basis for these studies offers little more than one set of metaphors (arranged around “cognition”) challenging another (“selfhood”). However, breaking the theoretical hold of protecting the immune self as the focus of immunology is no mean feat in terms of shifting research interest towards a key, but neglected aspect of immunity.

: Despite the development of a vast body of literature pertaining to feminism and science, examples of how feminist philosophies might be applied to scientific theories and practice have been limited. Moreover, most scientists remain unfamiliar with how feminism pertains to their work. Using the example of the immune system, this paper applies three feminist epistemologies--feminist empiricism, feminist standpoint theory, and feminist postmodernism--to assess competing claims of immune function within a feminist context.

The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.

Stress-induced brain-mediated immunoregulation is effected by two pathways: autonomic outflow and (neuro)endocrine outflow. Particular attention is given to the interaction-effects of chronic an acute stress. Recent data have established that cells of the immune system produce neuro-peptides and hormones. In concert with cytokines released by these immune cells the brain can be informed on the nature of ongoing immune activity. The significance of conditioning of immune responses is discussed.

In the following pages we propose a theory on cognitive systems and the common strategies of perception, which are at the basis of their function. We demonstrate that these strategies are easily seen to be in place in known cognitive systems such as vision and language. Furthermore we show that taking these strategies into consideration implies a new outlook on immune function calling for a new appraisal of the immune system as a cognitive system.

It is accepted that first-person thoughts are immune to error through misidentification. I argue that there is also immunity to error through misascription, failure to recognise which has resulted in mistaken claims that first-person thoughts involving the self-ascription of bodily states are, at best, circumstantially immune to error through misidentification relative to.

According to Mohan Matthen and Edwin Levy, certain immunological processes require explanations in which the immune system is attributed intentional states. This, they think, strengthens the scientific credentials of intentional psychology and undermines the position of those who argue that the scientific treatment of human action should involve the elimination of intentional description. In this paper, I argue that immunology does not and need not employ intentional explanation or description and consequently has nothing to offer those who seek to defend the scientific standing of intentional psychology by looking for other disciplines that "accommodate the intentional".