David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Journal of Medical Ethics 39 (12):761-764 (2013)
Ethical concerns have been raised about the quality of informed consent by participants in phase 1 oncology trials. Interview surveys indicate that substantial proportions of trial participants do not understand the purpose of these trials—evaluating toxicity and dosing for subsequent efficacy studies—and overestimate the prospect of therapeutic benefit that they offer. In this article we argue that although these data suggest the desirability of enhancing the process of information disclosure and assessment of comprehension of the implications of study participation, they do not necessarily invalidate consent by phase 1 trial participants
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
Paul S. Appelbaum, Loren H. Roth, Charles W. Lidz, Paul Benson & William Winslade (1987). False Hopes and Best Data: Consent to Research and the Therapeutic Misconception. Hastings Center Report 17 (2):20-24.
Tom L. Beauchamp (2009). Principles of Biomedical Ethics. Oxford University Press.
Allen E. Buchanan (1989). Deciding for Others: The Ethics of Surrogate Decisionmaking. Cambridge University Press.
Lynn A. Jansen, Paul S. Appelbaum, William Mp Klein, Neil D. Weinstein, William Cook, Jessica S. Fogel & Daniel P. Sulmasy (2011). Unrealistic Optimism in Early-Phase Oncology Trials. Irb 33 (1):1.
Nancy E. Kass, Jeremy Sugarman, Amy M. Medley, Linda A. Fogarty, Holly A. Taylor, Christopher K. Daugherty, Mark R. Emerson, Steven N. Goodman, Fay J. Hlubocky & Herbert I. Hurwitz (2009). An Intervention to Improve Cancer Patients' Understanding of Early-Phase Clinical Trials. Irb 31 (3):1.
Citations of this work BETA
No citations found.
Similar books and articles
Jane L. Hutton & Richard E. Ashcroft (2000). Some Popular Versions of Uninformed Consent. Health Care Analysis 8 (1):41-53.
Piotr Zaborowski & Adam Górski (2004). Informed Consent and the Use of Placebo in Poland: Ethical and Legal Aspects. Science and Engineering Ethics 10 (1):167-178.
W. Glannon (2006). Phase I Oncology Trials: Why the Therapeutic Misconception Will Not Go Away. Journal of Medical Ethics 32 (5):252-255.
Deborah Bowman (2011). Informed Consent: A Primer for Clinical Practice. Cambridge University Press.
A. T. Nuyen (2007). Knowing the Unknown and Informed Consent. International Journal of Applied Philosophy 21 (2):213-223.
Franklin G. Miller & Alan Wertheimer (2011). The Fair Transaction Model of Informed Consent: An Alternative to Autonomous Authorization. Kennedy Institute of Ethics Journal 21 (3):201-218.
Dennis Drotar, Victoria Miller, Victoria Willard, Kyle Anthony & Eric Kodish (2004). Correlates of Parental Participation During Informed Consent for Randomized Clinical Trials in the Treatment of Childhood Leukemia. Ethics and Behavior 14 (1):1 – 15.
Hans-Martin Sass (1998). Genotyping in Clinical Trials: Towards a Principle of Informed Request. Journal of Medicine and Philosophy 23 (3):288 – 296.
N. Waller Bruce (1995). Individual Autonomy and the Double-Blind Controlled Experiment: The Case of Desperate Volunteers. Journal of Medicine and Philosophy 20 (1).
Shaun D. Pattinson (2009). Consent and Informational Responsibility. Journal of Medical Ethics 35 (3):176-179.
F. G. Miller & T. J. Kaptchuk (2007). Acupuncture Trials and Informed Consent. Journal of Medical Ethics 33 (1):43-44.
Fred Gifford (1986). The Conflict Between Randomized Clinical Trials and the Therapeutic Obligation. Journal of Medicine and Philosophy 11 (4):347-366.
David Shaw (2009). Prescribing Placebos Ethically: The Appeal of Negatively Informed Consent. Journal of Medical Ethics 35 (2):97-99.
Sheila McLean (2010). Autonomy, Consent and the Law. Routledge-Cavendish.
Sorry, there are not enough data points to plot this chart.
Added to index2012-11-18
Total downloads1 ( #446,540 of 1,102,965 )
Recent downloads (6 months)1 ( #297,509 of 1,102,965 )
How can I increase my downloads?