David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
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Journal of Medical Ethics 39 (12):761-764 (2013)
Ethical concerns have been raised about the quality of informed consent by participants in phase 1 oncology trials. Interview surveys indicate that substantial proportions of trial participants do not understand the purpose of these trials—evaluating toxicity and dosing for subsequent efficacy studies—and overestimate the prospect of therapeutic benefit that they offer. In this article we argue that although these data suggest the desirability of enhancing the process of information disclosure and assessment of comprehension of the implications of study participation, they do not necessarily invalidate consent by phase 1 trial participants
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References found in this work BETA
Paul S. Appelbaum, Loren H. Roth, Charles W. Lidz, Paul Benson & William Winslade (1987). False Hopes and Best Data: Consent to Research and the Therapeutic Misconception. Hastings Center Report 17 (2):20-24.
Tom L. Beauchamp (2009). Principles of Biomedical Ethics. Oxford University Press.
Allen E. Buchanan (1989). Deciding for Others: The Ethics of Surrogate Decisionmaking. Cambridge University Press.
Lynn A. Jansen, Paul S. Appelbaum, William Mp Klein, Neil D. Weinstein, William Cook, Jessica S. Fogel & Daniel P. Sulmasy (2011). Unrealistic Optimism in Early-Phase Oncology Trials. Irb 33 (1):1.
Nancy E. Kass, Jeremy Sugarman, Amy M. Medley, Linda A. Fogarty, Holly A. Taylor, Christopher K. Daugherty, Mark R. Emerson, Steven N. Goodman, Fay J. Hlubocky & Herbert I. Hurwitz (2009). An Intervention to Improve Cancer Patients' Understanding of Early-Phase Clinical Trials. Irb 31 (3):1.
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