Graduate studies at Western
Acta Biotheoretica 49 (4) (2001)
|Abstract||Despite the recent progress in the description of the molecular mechanisms of proliferation and differentiation controls in vitro, the regulation of the homeostasis of normal stratified epithelia remains unclear in vivo. Computer simulation represents a powerful tool to investigate the complex field of cell proliferation regulation networks. It provides huge computation capabilities to test, in a dynamic in silico context, hypotheses about the many pathways and feedback loops involved in cell growth and proliferation controls.Our approach combines a model of cell proliferation and a spatial representation of cells in 2D using the Voronoi graph. The cell proliferation model includes intracellular (cyclins, Cyclin Dependent Kinases - CDKs, Retinoblastoma protein - Rb, CDK inhibitors) and extracellular controls (growth and differentiation factors, integrins). The Voronoi graph associates a polygon with every cell and the set of these polygons defines the tissue architecture. Thus, the model provides a quantitative model of extracellular signals and cell motility as a function of the neighborhood during time dependent simulations.|
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
Jean-Pierre Boissel (2010). In Silico Study of the Influence of Intensity and Duration of Blood Flow Reduction on Cell Death Through Necrosis or Apoptosis During Acute Ischemic Stroke. Acta Biotheoretica 58 (2):171-190.
Loïc Forest, Jaime San Martín, Fernando Padilla, Fabrice Chassat, Françoise Giroud & Jacques Demongeot (2004). Morphogenetic Processes: Application to Cambial Growth Dynamics. Acta Biotheoretica 52 (4).
Pierre Auger, Peter Dörmer & Joachim W. Ellwart (1992). Growth Factors and Cell Kinetics: A Mathematical Model Applied to Il-3 Deprivation on Leukemic Cell Lines. Acta Biotheoretica 40 (2-3).
Philippe Tracqui & Jacques Ohayon (2004). Transmission of Mechanical Stresses Within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model. Acta Biotheoretica 52 (4).
D. Manoussaki, S. R. Lubkin, R. B. Vemon & J. D. Murray (1996). A Mechanical Model for the Formation of Vascular Networks in Vitro. Acta Biotheoretica 44 (3-4).
A. Lasotal, K. Loskot & M. C. Mackey (1991). Stability Properties of Proliferatively Coupled Cell Replication Models. Acta Biotheoretica 39 (1).
F. Bailly, F. Gaill & R. Mosseri (1991). A Dynamical System for Biological Development: The Case of Caenorhabditis Elegans. Acta Biotheoretica 39 (3-4).
Loïc Forest & Jacques Demongeot (forthcoming). A General Formalism for Tissue Morphogenesis Based on Cellular Dynamics and Control System Interactions. Acta Biotheoretica.
Carole J. Clem & Jean Paul Rigaut (1995). Computer Simulation Modelling and Visualization of 3d Architecture of Biological Tissues. Acta Biotheoretica 43 (4).
Added to index2009-01-28
Total downloads2 ( #246,694 of 739,462 )
Recent downloads (6 months)1 ( #61,680 of 739,462 )
How can I increase my downloads?