Acta Biotheoretica 58 (4):315-327 (2010)
|Abstract||Secretion is a fundamental cellular process involving the regulated release of intracellular products from cells. Physiological functions such as neurotransmission, or the release of hormones and digestive enzymes, are all governed by cell secretion. Anomalies in the processes involved in secretion contribute to the development and progression of diseases such as diabetes and other hormonal disorders. To unravel the mechanisms that govern such diseases, it is essential to understand how hormones, growth factors and neurotransmitters are synthesized and processed, and how their signals are recognized, amplified and transmitted by intracellular signaling pathways in the target cells. Here, we discuss diverse aspects of the detailed mechanisms involved in secretion based on mathematical models. The models range from stochastic ones describing the trafficking of secretory vesicles to deterministic ones investigating the regulation of cellular processes that underlie hormonal secretion. In all cases, the models are closely related to experimental results and suggest theoretical predictions for the secretion mechanisms|
|Keywords||No keywords specified (fix it)|
|Through your library||Configure|
Similar books and articles
Melinda Fagan (2012). Waddington Redux: Models and Explanation in Stem Cell and Systems Biology. Biology and Philosophy 27 (2):179-213.
William Bechtel & Adele Abrahamsen (2010). Dynamic Mechanistic Explanation: Computational Modeling of Circadian Rhythms as an Exemplar for Cognitive Science. Studies in History and Philosophy of Science Part A 41 (3):321-333.
Didier Morel, Raphaël Marcelpoil & Gérard Brugal (2001). A Proliferation Control Network Model: The Simulation of Two-Dimensional Epithelial Homeostasis. Acta Biotheoretica 49 (4).
Philip Hahnfeldt (forthcoming). Quantitative Modeling of Tumor Dynamics and Radiotherapy. Acta Biotheoretica.
Lois Isenman (2009). Trusting Your Gut, Among Other Things: Digestive Enzyme Secretion, Intuition, and the History of Science. Foundations of Science 14 (4).
William Bechtel (2010). The Cell: Locus or Object of Inquiry? Studies in History and Philosophy of Science Part C 41 (3):172-182.
Philippe Tracqui & Jacques Ohayon (2004). Transmission of Mechanical Stresses Within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model. Acta Biotheoretica 52 (4).
William Bechtel (2007). In Search of Mitochondrial Mechanisms: Interfield Excursions Between Cell Biology and Biochemistry. Journal of the History of Biology 40 (1):1 - 33.
Lois Isenman (2009). Digestive Enzyme Secretion, Intuition, and the History of Science: Part II. Foundations of Science 14 (4).
Scott E. Christensen & S. Marc Breedlove (1998). Seductive Allure of Dichotomies. Behavioral and Brain Sciences 21 (3):367-367.
Sorry, there are not enough data points to plot this chart.
Added to index2010-07-31
Total downloads1 ( #274,556 of 548,984 )
Recent downloads (6 months)0
How can I increase my downloads?