Bias and Conditioning in Sequential Medical Trials

Philosophy of Science 80 (5):1053-1064 (2014)
Randomized controlled trials are currently the gold standard within evidence-based medicine. Usually they are monitored for early signs of effectiveness or harm. However, evidence from trials stopped early is often charged with bias toward implausibly large effects. To our mind, this skeptical attitude is unfounded and caused by the failure to perform appropriate conditioning in the statistical analysis of the evidence. We contend that conditional hypothesis tests give a superior appreciation of the obtained evidence and significantly improve the practice of sequential medical trials, while staying firmly rooted in frequentist methodology
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References found in this work BETA
Cecilia Nardini (2013). Monitoring in Clinical Trials: Benefit or Bias? Theoretical Medicine and Bioethics 34 (4):259-274.
John Worrall (2008). Evidence and Ethics in Medicine. Perspectives in Biology and Medicine 51 (3):418-431.
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