Strategies to improve the reliability of a theory: The experiment of bacterial invasion into cultured epithelial cells
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
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Studies in History and Philosophy of Science Part C 34 (4):593-614 (2003)
An analysis is presented of published methods that have been used by experimenters to justify the reliability of the theory of invasion of microorganisms into cultured cells. The results show that, to demonstrate this invasion, many experimenters used two or more methods that were based on independent technical and theoretical principles, and by doing so improved the reliability of the theory. Subsequently I compare this strategy of 'multiple derivability' with other strategies, discussed in the literature in relation to the mesosome, a bacterial organelle that had been detected with the electron microsope, but which appeared later to be an artifact. I propose that different strategies have been applied in this problem, and multiple derivability may have been the decisive one. Finally I discuss the idea that multiple derivability may help to anchor theories in a larger network of theories.
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References found in this work BETA
Sylvia Culp (1994). Defending Robustness: The Bacterial Mesosome as a Test Case. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1994:46 - 57.
Sylvia Culp (1995). Objectivity in Experimental Inquiry: Breaking Data-Technique Circles. Philosophy of Science 62 (3):438-458.
Robert G. Hudson (1999). Mesosomes: A Study in the Nature of Experimental Reasoning. Philosophy of Science 66 (2):289-309.
H. Nederbragt (2000). The Biomedical Disciplines and the Structure of Biomedical and Clinical Knowledge. Theoretical Medicine and Bioethics 21 (6):553-566.
Nicolas Rasmussen (2001). Evolving Scientific Epistemologies and the Artifacts of Empirical Philosophy of Science: A Reply Concerning Mesosomes. [REVIEW] Biology and Philosophy 16 (5):627-652.
Citations of this work BETA
Hubertus Nederbragt (2015). Cells That Count: Networks of a Diagnostic Test for Bovine Mastitis. Social Epistemology 29 (2):234-247.
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