The new mutation theory of phenotypic evolution
Proc Natl Acad Sci U S A 104 (30):12335-12242 (2007)
| Abstract | Recent studies of developmental biology have shown that the genes controlling phenotypic characters expressed in the early stage of development are highly conserved and that recent evolutionary changes have occurred primarily in the characters expressed in later stages of development. Even the genes controlling the latter characters are generally conserved, but there is a large component of neutral or nearly neutral genetic variation within and between closely related species. Phenotypic evolution occurs primarily by mutation of genes that interact with one another in the developmental process. The enormous amount of phenotypic diversity among different phyla or classes of organisms is a product of accumulation of novel mutations and their conservation that have facilitated adaptation to different environments. Novel mutations may be incorporated into the genome by natural selection (elimination of preexisting genotypes) or by random processes such as genetic and genomic drift. However, once the mutations are incorporated into the genome, they may generate developmental constraints that will affect the future direction of phenotypic evolution. It appears that the driving force of phenotypic evolution is mutation, and natural selection is of secondary importance. | |||||||||
| Keywords | evolutionary theory new mutations selection | |||||||||
| Categories | ||||||||||
| Options |
|
|||||||||
Download options| PhilPapers Archive |
Upload a copy of this paper Check publisher's policy on self-archival Papers currently archived: 5,875 |
| External links |
  Try with proxy. |
| Through your library | Configure |
Similar books and articlesMassimo Pigliucci (2003). Phenotypic Integration: Studying the Ecology and Evolution of Complex Phenotypes. Ecology Letters 6:265-272.
Jerry Fodor (2008). Against Darwinism. Mind and Language 23 (1):1–24.
Timothy Shanahan (1990). Evolution, Phenotypic Selection, and the Units of Selection. Philosophy of Science 57 (2):210-225.
Roberta L. Millstein (2007). Hsp90-Induced Evolution: Adaptationist, Neutralist, and Developmentalist Scenarios. Biological Theory: Integrating Development, Evolution and Cognition 2 (4):376-386.
Massimo Pigliucci & Carl D. Schlichting (1997). On the Limits of Quantitative Genetics for the Study of Phenotypic Evolution. Acta Biotheoretica 45 (2):143-160.
Michael B.�Lker (2004). Bear Ye One Another?S Genetic Burdens: The Price of Diversity and Complexity. Poiesis and Praxis 3 (1-2):73-82.
Michael Bölker (2004). Bear Ye One Another's Genetic Burdens: The Price of Diversity and Complexity. Poiesis and Praxis 3 (s 1-2):73-82.
Massimo Pigliucci, Courtney Murren & Carl Schlichting (2006). Phenotypic Plasticity and Evolution by Genetic Assimilation. Journal of Experimental Biology 209:2362-2367.
Giuseppe Fusco (2001). How Many Processes Are Responsible for Phenotypic Evolution? Evolution & Development 3 (4):279-286.
Giuseppe Fusco (2001). How Many Processes Are Responsible for Phenotypic Evolution? Evolution & Development 3 (4):279-286.
Analytics
Monthly downloads
Sorry, there are not enough data points to plot this chart.
|
Added to index2009-12-02Total downloads6 ( #147,054 of 556,837 )Recent downloads (6 months)0How can I increase my downloads? |
My notes
Discussion
