Reconciling the mutation-selection balance model with the schizotypy-creativity connection

Behavioral and Brain Sciences 29 (4):418-418 (2006)
Keller & Miller (K&M) make a persuasive case for the role of mutation-selection balance in the persistence of such disorders as schizophrenia. However, there is evidence relating illness liability to creativity, which seems to imply balancing selection. I argue for a hybrid position, where schizotypal personality traits can have fitness advantages or disadvantages, with mutational load and neurodevelopmental conditions determining which outcome is observed. (Published Online November 9 2006).
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DOI 10.1017/S0140525X06359092
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Tim Lewens (2010). The Natures of Selection. British Journal for the Philosophy of Science 61 (2):313-333.

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