David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 46 (4) (1998)
With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in micro-organisms, only those genes (e.g. p53) that enable the cells to escape from apoptosis may be selected.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
W. Schwemmler (1982). The Endoeytobiotic Cell Theory and the Periodic System of Cells. Acta Biotheoretica 31 (1).
Robert W. Korn (1993). Apical Cells as Meristems. Acta Biotheoretica 41 (3).
Armando Aranda-Anzaldo (2001). Cancer Development and Progression: A Non-Adaptive Process Driven by Genetic Drift. Acta Biotheoretica 49 (2).
Andrew Reynolds (2008). Amoebae as Exemplary Cells: The Protean Nature of an Elementary Organism. [REVIEW] Journal of the History of Biology 41 (2):307 - 337.
I. Bubanovic & S. Najman (2004). Ideas in Theoretical Biology - Failure of Anti-Tumor Immunity in Mammals - Evolution of the Hypothesis. Acta Biotheoretica 52 (1).
Melinda B. Fagan (2011). Social Experiments in Stem Cell Biology. Perspectives on Science 19 (3):235-262.
Berit Brogaard (2004). Species as Individuals. Biology and Philosophy 19 (2):223-242.
Deng K. Niu, Jia-Kuan Chen & Yong-Ding Liu (2001). Margulis' Theory on Division of Labour in Cells Revisited. Acta Biotheoretica 49 (1).
Deng K. Niu & Ya F. Wang (1995). Why Animals Have Tumours. Acta Biotheoretica 43 (3).
Added to index2009-01-28
Total downloads2 ( #366,304 of 1,101,860 )
Recent downloads (6 months)1 ( #306,556 of 1,101,860 )
How can I increase my downloads?