David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Behavioral and Brain Sciences 25 (5):555-577 (2002)
Differential diagnosis of motor symptoms, for example, akinesia, may be difficult in clinical neuropsychiatry. Symptoms may be either of neurologic origin, for example, Parkinson's disease, or of psychiatric origin, for example, catatonia, leading to a so-called “conflict of paradigms.” Despite their different origins, symptoms may appear more or less clinically similar. Possibility of dissociation between origin and clinical appearance may reflect functional brain organisation in general, and cortical-cortical/subcortical relations in particular. It is therefore hypothesized that similarities and differences between Parkinson's disease and catatonia may be accounted for by distinct kinds of modulation between cortico-cortical and cortico-subcortical relations. Catatonia can be characterized by concurrent motor, emotional, and behavioural symptoms. The different symptoms may be accounted for by dysfunction in orbitofrontal-prefrontal/parietal cortical connectivity reflecting “horizontal modulation” of cortico-cortical relation. Furthermore, alteration in “top-down modulation” reflecting “vertical modulation” of caudate and other basal ganglia by GABA-ergic mediated orbitofrontal cortical deficits may account for motor symptoms in catatonia. Parkinson's disease, in contrast, can be characterized by predominant motor symptoms. Motor symptoms may be accounted for by altered “bottom-up modulation” between dopaminergic mediated deficits in striatum and premotor/motor cortex. Clinical similarities between Parkinson's disease and catatonia with respect to akinesia may be related with involvement of the basal ganglia in both disorders. Clinical differences with respect to emotional and behavioural symptoms may be related with involvement of different cortical areas, that is, orbitofrontal/parietal and premotor/motor cortex implying distinct kinds of modulation – “vertical” and “horizontal” modulation, respectively. Key Words: Bottom-up modulation; catatonia; horizontal modulation; Parkinson's disease; top-down modulation; vertical modulation.
|Keywords||Bottom-up modulation catatonia horizontal modulation Parkinson's disease top-down modulation vertical modulation|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Georg Northoff (2002). Neurophysiology, Neuropsychiatry and Neurophilosophy of Catatonia. Behavioral and Brain Sciences 25 (5):592-599.
Martin Sarter & Gary G. Berntson (2004). Underconstrained Thalamic Activation + Underconstrained Top-Down Modulation of Cortical Input Processing = Underconstrained Perceptions. Behavioral and Brain Sciences 27 (6):803-804.
Rajendra D. Badgaiyan (2002). Nonconscious Processing, Anterior Cingulate, and Catatonia. Behavioral and Brain Sciences 25 (5):578-579.
Irwin Savodnik (2002). The Disease Status of Catatonia. Behavioral and Brain Sciences 25 (5):590-591.
John C. Marshall, Jennifer M. Gurd & Gereon R. Fink (2002). Catatonia, Motor Neglect, and Hysterical Paralysis: Some Similarities and Differences. Behavioral and Brain Sciences 25 (5):587-588.
Carrie E. Bearden & John R. Monterosso (2002). Catatonia Isn't Ready for a Unified Theory. Behavioral and Brain Sciences 25 (5):579-580.
Ayeesha K. Kamal & Nicholas D. Schiff (2002). Does the Form of Akinetic Mutism Linked to Mesodiencephalic Injuries Bridge the Double Dissociation of Parkinson's Disease and Catatonia? Behavioral and Brain Sciences 25 (5):586-587.
Brendan T. Carroll (2002). What Medical Catatonias Tell Us About Top-Down Modulation. Behavioral and Brain Sciences 25 (5):581-582.
André Aleman & René S. Kahn (2002). Top-Down Modulation, Emotion, and Hallucination. Behavioral and Brain Sciences 25 (5):578-578.
Bernhard Bogerts (2002). Does Catatonia Have a Specific Brain Biology? Behavioral and Brain Sciences 25 (5):580-581.
Added to index2009-01-28
Total downloads18 ( #94,585 of 1,103,008 )
Recent downloads (6 months)3 ( #120,820 of 1,103,008 )
How can I increase my downloads?