David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
History and Philosophy of the Life Sciences 29 (3):337 - 360 (2007)
Exploratory experimentation and high-throughput molecular biology appear to have considerable affinity for each other. Included in the latter category is metagenomics, which is the DNA-based study of diverse microbial communities from a vast range of non-laboratory environments. Metagenomics has already made numerous discoveries and these have led to reinterpretations of fundamental concepts of microbial organization, evolution, and ecology. The most outstanding success story of metagenomics to date involves the discovery of a rhodopsin gene, named proteorhodopsin, in marine bacteria that were never suspected to have any photobiological capacities. A discussion of this finding and its detailed investigation illuminates the relationship between exploratory experimentation and metagenomics. Specifically, the proteorhodopsin story indicates that a dichotomous interpretation of theory-driven and exploratory experimentation is insufficient and that an interactive understanding of these two types of experimentation can be usefully supplemented by another category, "natural history experimentation". Further reflection on the context of metagenomics suggests the necessity of thinking more historically about exploratory and other forms of experimentation
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
Sabina Leonelli & Rachel A. Ankeny (2012). Re-Thinking Organisms: The Impact of Databases on Model Organism Biology. Studies in History and Philosophy of Science Part C 43 (1):29-36.
Rachel A. Ankeny & Sabina Leonelli (2011). What's so Special About Model Organisms? Studies in History and Philosophy of Science Part A 42 (2):313-323.
Sara Green (2013). When One Model is Not Enough: Combining Epistemic Tools in Systems Biology. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):170-180.
Chris Haufe (2013). Why Do Funding Agencies Favor Hypothesis Testing? Studies in History and Philosophy of Science Part A 44 (3):363-374.
Maureen A. O'Malley, Kevin C. Elliott & Richard M. Burian (2010). From Genetic to Genomic Regulation: Iterativity in microRNA Research. Studies in History and Philosophy of Science Part C 41 (4):407-417.
Similar books and articles
John Dupré & Maureen A. O'Malley (2007). Metagenomics and Biological Ontology. Studies in History and Philosophy of Science Part C 38 (4):834-846.
Friedrich Steinle (1997). Entering New Fields: Exploratory Uses of Experimentation. Philosophy of Science 64 (4):74.
Richard M. Burian (2007). On MicroRNA and the Need for Exploratory Experimentation in Post-Genomic Molecular Biology. History and Philosophy of the Life Sciences 29 (3):285 - 311.
Kevin Elliott (2007). Varieties of Exploratory Experimentation in Nanotoxicology. History and Philosophy of the Life Sciences 29 (3):313 - 336.
Jane Maienschein (1986). Arguments for Experimentation in Biology. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1986:180 - 195.
L. R. Franklin (2005). Exploratory Experiments. Philosophy of Science 72 (5):888-899.
John Dupré & Maureen A. O’Malley (2007). Metagenomics and Biological Ontology. Studies in History and Philosophy of Science Part C 38 (4):834-846.
C. Kenneth Waters (2007). The Nature and Context of Exploratory Experimentation: An Introduction to Three Case Studies of Exploratory Research. History and Philosophy of the Life Sciences 29 (3):275 - 284.
Added to index2009-01-28
Total downloads11 ( #141,141 of 1,099,558 )
Recent downloads (6 months)1 ( #300,754 of 1,099,558 )
How can I increase my downloads?