David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Studies in History and Philosophy of Science Part C 41 (4):407-417 (2010)
The discovery and ongoing investigation of microRNAs suggest important conceptual and methodological lessons for philosophers and historians of biology. This paper provides an account of miRNA research and the shift from viewing these tiny regulatory entities as minor curiosities to seeing them as major players in the post-transcriptional regulation of genes. Conceptually, the study of miRNAs is part of a broader change in understandings of genetic regulation, in which simple switch-like mechanisms were reinterpreted as aspects of complex cellular and genome-wide processes. Among them are the activities of small RNAs, previously regarded as non-functional. Methodologically, the miRNA story suggests new ways of characterizing biological research that should prove helpful to philosophers of science who seek to develop more pluralistic, pragmatic models of scientific inquiry. miRNA research displays iterative movements between multiple modes of investigation that include not only the proposal and testing of hypotheses but also exploratory, technology-oriented and question-driven modes of research. As an exemplary story of scientific discovery and development, the miRNA case illustrates transitions from genetics to genomics and systems biology, and it shows how diverse configurations of research practice are related to major scientific advances
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
John F. Allen (2001). Bioinformatics and Discovery: Induction Beckons Again. Bioessays 23 (1):104-107.
Rachel A. Ankeny (2000). Fashioning Descriptive Models in Biology: Of Worms and Wiring Diagrams. Philosophy of Science 67 (3):272.
John Beatty (1997). Why Do Biologists Argue Like They Do? Philosophy of Science 64 (4):443.
Richard M. Burian (1997). Exploratory Experimentation and the Role of Histochemical Techniques in the Work of Jean Brachet, 1938-1952. History and Philosophy of the Life Sciences 19 (1):27 - 45.
Citations of this work BETA
Werner Callebaut (2013). Naturalizing Theorizing: Beyond a Theory of Biological Theories. [REVIEW] Biological Theory 7 (4):413-429.
Werner Callebaut (2011). Beyond Generalized Darwinism. II. More Things in Heaven and Earth. Biological Theory 6 (4):351-365.
Similar books and articles
Sarah Knerr, Dawn Wayman & Vence L. Bonham (2011). Inclusion of Racial and Ethnic Minorities in Genetic Research: Advance the Spirit by Changing the Rules? Journal of Law, Medicine and Ethics 39 (3):502-512.
Richard M. Burian (2007). On MicroRNA and the Need for Exploratory Experimentation in Post-Genomic Molecular Biology. History and Philosophy of the Life Sciences 29 (3):285 - 311.
Ben Chan, Flavia M. Facio, Haley Eidem, Sara Chandros Hull, Leslie G. Biesecker & Benjamin E. Berkman (2012). Genomic Inheritances: Disclosing Individual Research Results From Whole-Exome Sequencing to Deceased Participants' Relatives. American Journal of Bioethics 12 (10):1-8.
Rogeer Hoedemaekers, Bert Gordijn & Martien Pijnenburg (2006). Does an Appeal to the Common Good Justify Individual Sacrifices for Genomic Research? Theoretical Medicine and Bioethics 27 (5):415-431.
Paulina Tindana, Susan Bull, Lucas Amenga-Etego, Jantina de Vries, Raymond Aborigo, Kwadwo Koram, Dominic Kwiatkowski & Michael Parker (2012). Seeking Consent to Genetic and Genomic Research in a Rural Ghanaian Setting: A Qualitative Study of the MalariaGEN Experience. [REVIEW] BMC Medical Ethics 13 (1):15-.
Bette Jacobs, Jason Roffenbender, Jeff Collmann, Kate Cherry, LeManuel Lee Bitsói, Kim Bassett & Charles H. Evans (2010). Bridging the Divide Between Genomic Science and Indigenous Peoples. Journal of Law, Medicine and Ethics 38 (3):684-696.
C. Simon, L. A. Shinkunas, D. Brandt & J. K. Williams (2012). Individual Genetic and Genomic Research Results and the Tradition of Informed Consent: Exploring US Review Board Guidance. Journal of Medical Ethics 38 (7):417-422.
Gordon R. Mitchell (2001). Defining the Subject of Consent in DNA Research. Journal of Medical Humanities 22 (1):41-53.
Judith Wagner DeCew (2004). Privacy and Policy for Genetic Research. Ethics and Information Technology 6 (1):5-14.
Colin Farrelly (2007). Genetic Justice Must Track Genetic Complexity. Cambridge Quarterly of Healthcare Ethics 17 (01):45-53.
Richard J. Davidson, Dysfunction in the Neural Circuitry of Emotion Regulation—A Possible Prelude to Violence.
Colin Farrelly (2004). Genes and Equality. Journal of Medical Ethics 30 (6):587-592.
Patrick Giam (2012). Preimplantation Genetic Diagnosis: A Perspective From Human Dignity`. Bioethics Research Notes 24 (3):40.
Ainsley Newson (2004). The Nature and Significance of Behavioural Genetic Information. Theoretical Medicine and Bioethics 25 (2):89-111.
Suli Sui & Margaret Sleeboom-Faulkner (2007). Commercial Genetic Testing in Mainland China: Social, Financial and Ethical Issues. [REVIEW] Journal of Bioethical Inquiry 4 (3):229-237.
Added to index2012-03-03
Total downloads4 ( #299,258 of 1,692,629 )
Recent downloads (6 months)3 ( #75,732 of 1,692,629 )
How can I increase my downloads?