Intervention, integration and translation in obesity research: Genetic, developmental and metaorganismal approaches
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
Learn more about PhilPapers
Philosophy, Ethics, and Humanities in Medicine 6 (1):2- (2011)
Obesity is the focus of multiple lines of inquiry that have -- together and separately -- produced many deep insights into the physiology of weight gain and maintenance. We examine three such streams of research and show how they are oriented to obesity intervention through multilevel integrated approaches. The first research programme is concerned with the genetics and biochemistry of fat production, and it links metabolism, physiology, endocrinology and neurochemistry. The second account of obesity is developmental and draws together epigenetic and environmental explanations that can be embedded in an evolutionary framework. The third line of research focuses on the role of gut microbes in the production of obesity, and how microbial activities interact with host genetics, development and metabolism. These interwoven explanatory strategies are driven by an orientation to intervention, both for experimental and therapeutic outcomes. We connect the integrative and intervention-oriented aspects of obesity research through a discussion of translation, broadening the concept to capture the dynamic, iterative processes of scientific practice and therapy development. This system-oriented analysis of obesity research expands the philosophical scrutiny of contemporary developments in the biosciences and biomedicine, and has the potential to enrich philosophy of science and medicine
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
Karola Stotz (2010). Human Nature and Cognitive–Developmental Niche Construction. Phenomenology and the Cognitive Sciences 9 (4):483-501.
Sabina Leonelli (2013). Integrating Data to Acquire New Knowledge: Three Modes of Integration in Plant Science. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):503-514.
Anna Laura van der Laan & Marianne Boenink (2012). Beyond Bench and Bedside: Disentangling the Concept of Translational Research. Health Care Analysis 23 (1):1-18.
Similar books and articles
Maureen O'Malley & Karola Stotz (2011). Intervention, Integration and Translation in Obesity Research: Genetic, Developmental and Metaorganismal Approaches. Philosophy, Ethics, and Humanities in Medicine 6 (1):1-14.
Jonny Anomaly (2012). Is Obesity a Public Health Problem? Public Health Ethics 5 (3):216-221.
Bennett Foddy (2011). Addicted to Food, Hungry for Drugs. Neuroethics 4 (2):79-89.
Y. Tony Yang & Len M. Nichols (2011). Obesity and Health System Reform: Private Vs. Public Responsibility. Journal of Law, Medicine & Ethics 39 (3):380-386.
Ross Upshur (2013). What Does Public Health Ethics Tell (Or Not Tell) Us About Intervening in Non-Communicable Diseases? Journal of Bioethical Inquiry 10 (1):19-28.
Jantina Vries (2007). The Obesity Epidemic: Medical and Ethical Considerations. [REVIEW] Science and Engineering Ethics 13 (1):55-67.
Jantina de Vries (2007). The Obesity Epidemic: Medical and Ethical Considerations. [REVIEW] Science and Engineering Ethics 13 (1):55-67.
C. A. Womack (2012). Public Health and Obesity: When a Pound of Prevention Really Is Worth an Ounce of Cure. Public Health Ethics 5 (3):222-228.
Norah Mulvaney-Day & Catherine A. Womack (2009). Obesity, Identity and Community: Leveraging Social Networks for Behavior Change in Public Health. Public Health Ethics 2 (3):250-260.
Jacquineau Azetsop & Tisha Joy (2011). Epistemological and Ethical Assessment of Obesity Bias in Industrialized Countries. Philosophy, Ethics, and Humanities in Medicine 6 (1):16-.
Jacquineau Azétsop & Tisha R. Joy (2011). Epistemological and Ethical Assessment of Obesity Bias in Industrialized Countries. Philosophy, Ethics, and Humanities in Medicine 6 (1):16-.
Sue A. Korol (2009). De-Signing Fat. International Journal of Applied Philosophy 23 (2):285-304.
Added to index2010-12-30
Total downloads22 ( #167,345 of 1,793,156 )
Recent downloads (6 months)5 ( #169,309 of 1,793,156 )
How can I increase my downloads?