Treatment of ADHD with methylphenidate may sensitize brain substrates of desire: Implications for changes in drug abuse potential from an animal model
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Consciousness and Emotion 3 (1):7-19 (2002)
Aims. Currently, methylphenidate (MPH, trade name Ritalin) is the most widely prescribed medication for attention deficit/hyperactivity disorder (ADHD). We examined the ability of repeated MPH administration to produce a sensitized appetitive eagerness type response in laboratory rats, as indexed by 50-kHz ultrasonic vocalizations (50-kHz USVs). We also examined the ability of MPH to reduce play behavior in rats which may be partially implicated in the clinical efficacy of MPH in ADHD. Design. 56 adolescent rats received injections of either 5.0 mg/kg MPH, or vehicle each day for 8 consecutive days, and a week later received a challenge injection of either MPH or vehicle. Measurements. Both play behavior (pins) and 50-kHz USVs were recorded after each drug or vehicle administration. Results. MPH challenge produced a substantial 73% reduction in play behavior during the initial treatment phase, and during the last test (1 week post drug), 50-kHz USVs were elevated approximately threefold only in animals with previous MPH experience. Conclusions. These data suggest that MPH treatment may lead to psychostimulant sensitization in young animals, perhaps by increasing future drug-seeking tendencies due to an elevated eagerness for positive incentives. Further, we hypothesize that MPH may be reducing ADHD symptoms, in part, by blocking playful tendencies, whose neuro-maturational and psychological functions remain to be adequately characterized.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
Gordon M. Burghardt (2006). Money, Play, and Instincts. Behavioral and Brain Sciences 29 (2):182-183.
John R. Leo & D. Cohen (2003). Broken Brains or Flawed Studies? A Critical Review of ADHD Neuroimaging Research. Journal of Mind and Behavior 24 (1):29-55.
Florence Levy (2005). ADHD, Comorbidity, Synaptic Gates and Re-Entrant Circuits. Behavioral and Brain Sciences 28 (3):434-435.
Susan C. C. Hawthorne (2010). Institutionalized Intolerance of ADHD: Sources and Consequences. Hypatia 25 (3):504 - 526.
Paul Cooper (2008). Like Alligators Bobbing for Poodles? A Critical Discussion of Education, Adhd and the Biopsychosocial Perspective. Journal of Philosophy of Education 42 (3-4):457-474.
Cynthia Forlini & Eric Racine (2009). Autonomy and Coercion in Academic “Cognitive Enhancement” Using Methylphenidate: Perspectives of Key Stakeholders. [REVIEW] Neuroethics 2 (3):163-177.
Michiel van Lambalgen, Claudia van Kruistum & Esther Parigger (2008). Discourse Processing in Attention-Deficit Hyperactivity Disorder (Adhd). Journal of Logic, Language and Information 17 (4):467-487.
Bonnie J. Kaplan (1999). The Neurobiology of Attention-Deficit/Hyperactivity Disorder (ADHD) as a Model of the Neurobiology of Personality. Behavioral and Brain Sciences 22 (3):526-527.
Cynthia Chappell & Nathan Carlin (2011). Public Health Ethics Education in a Competency-Based Curriculum: A Method of Programmatic Assessment. [REVIEW] Journal of Academic Ethics 9 (1):33-42.
Aribert Rothenberger & Roumen Kirov (2005). Changes in Sleep-Wake Behavior May Be More Than Just an Epiphenomenon of ADHD. Behavioral and Brain Sciences 28 (3):439-439.
Added to index2009-01-28
Total downloads9 ( #126,509 of 1,004,651 )
Recent downloads (6 months)1 ( #64,617 of 1,004,651 )
How can I increase my downloads?