'Trouble from within': Allergy, autoimmunity, and pathology in the first half of the twentieth century
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Studies in History and Philosophy of Science Part C 34 (3):425-454 (2003)
Traditionally, autoimmune disease has been considered to be a case of false recognition; the immune system mistakenly identifies 'self' tissues as foreign, attacking them thus causing damage and malady. Accordingly, the history of autoimmunity is usually told as part ot the history of immunology, that is, of theories and experiments relating to the ability of the immune system to discriminate between self and nonself. This paper challenges this view, claiming that the emergence of the notion of autoimmunity in the 1950s must be considered as part of a long develolpment in thought about pathology throughout the twentieth century, namely the conceptualisaiton of disease as a reactive and self-destructive process. During the first part of the twentieth century this notion became one of the cornerstones of pathology and was increasingly employed for the explanation of the non-infections, slow-burning diseases. Thus, the category of chronic disease had been defined anew, now encompassing all those diseases characterised by a persistent inflammatory process. Inflammation, in turn, was conceived as double-eged physiological mechanism, which was usually the direct mediator of damage, of the essence of disease. The paper also shows how this kind of analysis could emable a unified historical discussion of autoimmunity and allergy, hitherto considered to have distinct conceptual origins.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
Michelle Jamieson (2010). Imagining 'Reactivity': Allergy Within the History of Immunology. Studies in History and Philosophy of Science Part C 41 (4):356-366.
Similar books and articles
Malcolm Horne (2010). Johnny Wilkinson's Addiction. Philosophy, Psychiatry, and Psychology 17 (1):31-34.
Martin Hägglund (2008). Radical Atheism: Derrida and the Time of Life. Stanford University Press.
Corneliu C. Simuţ (2010). Traditionalism and Radicalism in the History of Christian Thought. Palgrave Macmillan.
Ed Cohen (2004). My Self as an Other: On Autoimmunity and “Other” Paradoxes. Medical Humanities 30 (1):7-11.
Michael Naas (2006). "One Nation … Indivisible": Jacques Derrida on the Autoimmunity of Democracy and the Sovereignty of God. Research in Phenomenology 36 (1):15-44.
G. Mitman (2003). Natural History and the Clinic: The Regional Ecology of Allergy in America. Studies in History and Philosophy of Science Part C 34 (3):491-510.
Sara Moghaddam-Taaheri (2011). Understanding Pathology in the Context of Physiological Mechanisms: The Practicality of a Broken-Normal View. Biology and Philosophy 26 (4):603-611.
M. la Caze (2011). Terrorism and Trauma: Negotiating Derridean 'Autoimmunity'. Philosophy and Social Criticism 37 (5):605-619.
William E. Stempsey (2000). A Pathological View of Disease. Theoretical Medicine and Bioethics 21 (4):321-330.
M. Jackson (2003). John Freeman, Hay Fever and the Origins of Clinical Allergy in Britain, 1900-1950. Studies in History and Philosophy of Science Part C 34 (3):473-490.
Added to index2009-01-28
Total downloads10 ( #156,754 of 1,139,990 )
Recent downloads (6 months)1 ( #157,514 of 1,139,990 )
How can I increase my downloads?