Nothing reliable about genes or environment: new perspectives on analysis of similarity among relatives in light of the possibility of underlying heterogeneity
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
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Studies in History and Philosophy of Science Part C 40 (3):210-220 (2009)
Despite the long history of scientific, philosophical, and political debate around heritability studies, certain fundamental conceptual issues have not been recognized or well appreciated. The starting point is that heritability does not measure the degree of influence that genes have on a trait or provide a reliable basis for choosing which traits to investigate further with molecular genetic research. The short argument on this point revolves around two issues: the disconnect between analyzing measurements of a trait and exposing the measurable genetic and environmental factors underlying the trait’s development; and the possibility of heterogeneity in these underlying factors, that is, different factors may lead to the same trait value. The idea of underlying heterogeneity is elaborated through schematic diagrams and distinguished from other senses of heterogeneity. Five conceptually distinct approaches for addressing underlying heterogeneity are identified, corresponding to distinct ways of managing the reciprocal relationship between the degree of knowledge of the dynamics through which the trait develops and the actions that can be reliably be based on what is known . This framework, which extends the interventionist notion of causality, allows the scope and limitations of heritability studies to be clarified in greater detail. It can also inform critical appreciation of newer methods of analysis of genetic and environmental factors. The issues discussed in this article do not centre on empirical data or technical detail and should be accessible to non-specialists as well as challenging active researchers
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References found in this work BETA
Omri Tal (2009). From Heritability to Probability. Biology and Philosophy 24 (1):81-105.
Peter Taylor (2006). Heritability and Heterogeneity: The Limited Relevance of Heritability in Investigating Genetic and Environmental Factors. Biological Theory 1 (2):150-164.
Peter J. Taylor (2008). The Under-Recognized Implications of Heterogeneity: Opportunities for Fresh Views on Scientific, Philosophical, and Social Debates About Heritability. History and Philosophy of the Life Sciences 30 (3/4):431 - 456.
Peter J. Taylor (2007). The Unreliability of High Human Heritability Estimates and Small Shared Effects of Growing Up in the Same Family. Biological Theory 2 (4):387-397.
Citations of this work BETA
Peter Taylor (2009). Perspectives From Plant Breeding on Tal's Argument About the Weight of Genetic Versus environmenTal Causes for Individuals. Biology and Philosophy 24 (5):735-738.
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