David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
Learn more about PhilPapers
Since its development about 15 years ago, functional magnetic resonance imaging (fMRI) has become the leading research tool for mapping brain activity. The technique works by detecting the levels of oxygen in the blood, point by point, throughout the brain. In other words, it relies on a surrogate signal, resulting from changes in oxygenation, blood volume and flow, and does not directly measure neural activity. Although a relationship between changes in brain activity and blood flow has long been speculated, indirectly examined and suggested and surely anticipated and expected, the neural basis of the fMRI signal was only recently demonstrated directly in experiments using combined imaging and intracortical recordings. In the present paper, we discuss the results obtained from such combined experiments. We also discuss our current knowledge of the extracellularly measured signals of the neural processes that they represent and of the structural and functional neurovascular coupling, which links such processes with the hemodynamic changes that offer the surrogate signal that we use to map brain activity. We conclude by considering applications of invasive MRI, including injections of paramagnetic tracers for the study of connectivity in the living animal and simultaneous imaging and electrical microstimulation. D 2004 Elsevier Inc. All rights reserved.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library||
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Andreas Bartels, fMRI and its Interpretations: An Illustration on Directional Selectivity in Area V5/MT.
Agnès Aubert, Robert Costalat, Hugues Duffau & Habib Benali (2002). Modeling of Pathophysiological Coupling Between Brain Electrical Activation, Energy Metabolism and Hemodynamics: Insights for the Interpretation of Intracerebral Tumor Imaging. Acta Biotheoretica 50 (4):281-295.
Steven Laureys & Serge Goldman (2004). Imagine Imaging Neural Activity in Crying Infants and in Their Caring Parents. Behavioral and Brain Sciences 27 (4):465-467.
Bettina Sorger & Audrey Maudoux, Another Kind of 'BOLD Response': Answering Multiple-Choice Questions Via Online Decoded Single-Trial Brain Signals.
Agnès Aubert, Robert Costalat & Romain Valabrègue (2001). Modelling of the Coupling Between Brain Electrical Activity and Metabolism. Acta Biotheoretica 49 (4):301-326.
Jocelyn Downie, Matthais Schmidt, Nuala Kenny, Ryan D’Arcy, Michael Hadskis & Jennifer Marshall (2007). Paediatric MRI Research Ethics: The Priority Issues. [REVIEW] Journal of Bioethical Inquiry 4 (2):85-91.
Hannah Fitsch (2012). (A)E(s)Th(Et)Ics of Brain Imaging. Visibilities and Sayabilities in Functional Magnetic Resonance Imaging. Neuroethics 5 (3):275-283.
Charles A. Nelson (2008). Incidental Findings in Magnetic Resonance Imaging (MRI) Brain Research. Journal of Law, Medicine & Ethics 36 (2):315-319.
Jacob Korf (2012). The Mind as an Emerging Configuration of the Personal Brain. Dialogues in Philosophy, Mental and Neuro Sciences 5 (1):21-24.
Richard A. A. Kanaan & Philip K. McGuire (2012). Conceptual Challenges in the Neuroimaging of Psychiatric Disorders. Philosophy, Psychiatry, and Psychology 18 (4):323-332.
Added to index2010-12-22
Total downloads20 ( #194,348 of 1,911,679 )
Recent downloads (6 months)1 ( #458,010 of 1,911,679 )
How can I increase my downloads?