David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Philosophical Transactions Royal Society B 365:557–566 (2010)
In a now classic paper published in 1991, Alberch introduced the concept of genotype–phenotype (G!P) mapping to provide a framework for a more sophisticated discussion of the integration between genetics and developmental biology that was then available. The advent of evo-devo first and of the genomic era later would seem to have superseded talk of transitions in phenotypic space and the like, central to Alberch’s approach. On the contrary, this paper shows that recent empirical and theoretical advances have only sharpened the need for a different conceptual treat- ment of how phenotypes are produced. Old-fashioned metaphors like genetic blueprint and genetic programme are not only woefully inadequate but positively misleading about the nature of G!P, and are being replaced by an algorithmic approach emerging from the study of a variety of actual G!P maps. These include RNA folding, protein function and the study of evolvable soft- ware. Some generalities are emerging from these disparate fields of analysis, and I suggest that the concept of ‘developmental encoding’ (as opposed to the classical one of genetic encoding) provides a promising computational–theoretical underpinning to coherently integrate ideas on evolvability, modularity and robustness and foster a fruitful framing of the G!P mapping problem.
|Keywords||evolvability genotype–phenotype mapping developmental encoding|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
Kevin N. Laland, John Odling-Smee, William Hoppitt & Tobias Uller (2013). More on How and Why: Cause and Effect in Biology Revisited. Biology and Philosophy 28 (5):719-745.
Maarten Boudry & Massimo Pigliucci (2013). The Mismeasure of Machine: Synthetic Biology and the Trouble with Engineering Metaphors. Studies in History and Philosophy of Biological and Biomedical Sciences (4):660-668.
Massimo Pigliucci (2013). What Are We to Make of the Concept of Race? Thoughts of a Philosopher–Scientist. Studies in History and Philosophy of Biological and Biomedical Sciences 44 (3):272-277.
Sara Green, Melinda Fagan & Johannes Jaeger (2015). Explanatory Integration Challenges in Evolutionary Systems Biology. Biological Theory 10 (1):18-35.
Sui Huang (2012). The Molecular and Mathematical Basis of Waddington's Epigenetic Landscape: A Framework for Post‐Darwinian Biology? Bioessays 34 (2):149-157.
Similar books and articles
Sylvia Culp (1997). Establishing Genotype/Phenotype Relationships: Gene Targeting as an Experimental Approach. Philosophy of Science 64 (4):278.
Kim Sterelny, Kelly C. Smith & Michael Dickison (1996). The Extended Replicator. Biology and Philosophy 11 (3):377-403.
Bradford Z. Mahon (2003). The Genetics of Environment and the Environment of Genotypes. Social Philosophy Today 19:79-87.
Brian K. Hall (2003). Unlocking the Black Box Between Genotype and Phenotype: Cell Condensations as Morphogenetic (Modular) Units. [REVIEW] Biology and Philosophy 18 (2):219-247.
Nicholas Agar (1996). Teleogy and Genes. Biology and Philosophy 11 (3):289-300.
Kathryn S. Plaisance, Thomas A. C. Reydon & Mehmet Elgin (2012). Why the (Gene) Counting Argument Fails in the Massive Modularity Debate: The Need for Understanding Gene Concepts and Genotype-Phenotype Relationships. Philosophical Psychology 25 (6):873-892.
Piotr Lenartowicz (1975). Phenotype-Genotype Dichotomy: An Essay in Theoretical Biology. Typis Pontificiae Universitatis Gregorianae.
Paul E. Griffiths & Karola Stotz (2006). Genes in the Postgenomic Era. Theoretical Medicine and Bioethics 27 (6):499-521.
Robert T. Pennock & Benjamin E. Beckmann, HybrID: A Hybridization of Indirect and Direct Encodings for Evolutionary Computation.
Richard Lewontin, The Genotype/Phenotype Distinction. Stanford Encyclopedia of Philosophy.
J. Scott Turner (2004). Extended Phenotypes and Extended Organisms. Biology and Philosophy 19 (3):327-352.
Kim Sterelny (2000). Development, Evolution, and Adaptation. Philosophy of Science 67 (3):387.
John Stewart (2002). Genetics, Biology and Multifactorial Diseases. Acta Biotheoretica 50 (4):323-329.
Kai Hahlweg (1981). Progress Through Evolution? An Inquiry Into the Thought of C.H. Waddington. Acta Biotheoretica 30 (2):103-120.
Added to index2011-03-21
Total downloads195 ( #6,936 of 1,725,835 )
Recent downloads (6 months)74 ( #14,467 of 1,725,835 )
How can I increase my downloads?