Théorie de la cible: Un modèle markovien pour l'évolution génétique d'une mutation latente

Acta Biotheoretica 22 (3):120-141 (1973)
Abstract
A hereditary character in individuals of the same species is envisaged as belonging to a “target” made up of several mutually independent particles, which can be manifested in diverse forms. The phenotype depends on the distribution of the different forms in the target. Cell fission then corresponds to a certain mode of division of the target, permitting particle transmission between generations. In this way the rules for appearance of various phenotypes are determined. The problem of determining the number of particles constituting a target is examined and a solution is given. This solution takes into account simultaneously three factors: a) mathematical , b) experimental and c) numerical .Chez les individus d'une mÊme espèce, un caractère héréditaire est supposé associé à une “cible” constituée de plusieurs particules, indépendantes entre elles, et susceptibles de se présenter sous diverses formes. Le phénotype dépend de la répartition de ces différentes formes dans la cible. A la division cellulaire correspond un certain mode de division de la cible, permettant la transmission des particules d'une génération à l'autre, et induisant des règles d'apparition des divers phénotypes. Le problème de la détermination du nombre des particules constituant la cible est examiné ici, et une solution est exposée. Cette solution tient compte à la fois des aspects mathématiques , expérimentaux et numériques
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