David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
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Studies in History and Philosophy of Biological and Biomedical Sciences 40 (1):54-64 (2009)
Although molecular biology has meant different things at different times, the term is often associated with a tendency to view cellular causation as conforming to simple linear schemas in which macro-scale effects are specified by micro-scale structures. The early achievements of molecular biologists were important for the formation of such an outlook, one to which the discovery of recombinant DNA techniques, and a number of other findings, gave new life even after the complexity of genotype–phenotype
relations had become apparent. Against this background we outline how a range of scientific developments and conceptual considerations can be regarded as enabling and perhaps necessitating contemporary systems approaches. We suggest that philosophical ideas have a valuable part to play in making sense of complex scientific and disciplinary issues.
|Keywords||molecular biology systems biology reductionism emergence mechanism networks|
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References found in this work BETA
Herbert A. Simon (1969). The Sciences of the Artificial. [Cambridge, M.I.T. Press.
Peter K. Machamer, Lindley Darden & Carl F. Craver (2000). Thinking About Mechanisms. Philosophy of Science 67 (1):1-25.
Stuart Glennan (2002). Rethinking Mechanistic Explanation. Proceedings of the Philosophy of Science Association 2002 (3):S342-353.
Carl F. Craver & William Bechtel (2007). Top-Down Causation Without Top-Down Causes. Biology and Philosophy 22 (4):547-563.
Maureen O'Malley, Alexander Powell, Jonathan Davies & Jane Calvert (2008). Knowledge-Making Distinctions in Synthetic Biology. Bioessays 30 (1):57-65.
Citations of this work BETA
Steven French (2010). The Interdependence of Structure, Objects and Dependence. Synthese 175 (S1):89 - 109.
Gil C. Santos (2015). Ontological Emergence: How is That Possible? Towards a New Relational Ontology. Foundations of Science 20 (4):429-446.
Daniel J. Nicholson (2014). The Return of the Organism as a Fundamental Explanatory Concept in Biology. Philosophy Compass 9 (5):347-359.
Andrew Reynolds (2010). The Redoubtable Cell. Studies in History and Philosophy of Science Part C 41 (3):194-201.
Lijing Jiang (2014). Causes of Aging Are Likely to Be Many: Robin Holliday and Changing Molecular Approaches to Cell Aging, 1963–1988. Journal of the History of Biology 47 (4):547-584.
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