David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
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Biology and Philosophy 21 (2):235-252 (2006)
The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for 60 years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity.
|Keywords||Continuity Identity Immunology Organism and environment Self|
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References found in this work BETA
David Wiggins (2001). Sameness and Substance Renewed. Cambridge University Press.
Humberto R. Maturana & Francisco G. Varela (1980). Autopoiesis and Cognition the Realization of the Living.
Richard C. Lewontin (2000). The Triple Helix: Gene, Organism, and Environment. Harvard University Press.
Aristotle (1960). Metaphysics. Univ of Michigan Pr.
Citations of this work BETA
Ellen Clarke (2011). The Problem of Biological Individuality. Biological Theory 5 (4):312-325.
Thomas Pradeu (2011). A Mixed Self: The Role of Symbiosis in Development. Biological Theory 6 (1):80-88.
Neeraja Sankaran (2013). Breaking with the Self: Can Continuity in Immunology Succeed? Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):242-246.
Ellen Clarke (2010). The Problem of Biological Individuality. Biological Theory 5 (4):312-325.
Matthew H. Haber (2014). In Defense of the Organism. Biology and Philosophy 29 (6):885-895.
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