David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Biology and Philosophy 21 (2):235-252 (2006)
The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for 60 years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity.
|Keywords||Continuity Identity Immunology Organism and environment Self|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
Thomas Pradeu (2010). What is an Organism? An Immunological Answer. History and Philosophy of the Life Sciences 32.
Moira Howes (2008). Conceptualizing the Maternal-Fetal Relationship in Reproductive Immunology. In Kenton Kroker, Jennifer Keelan & Pauline Mazumdar (eds.), Crafting Immunity: Working Histories of Clinical Immunology. Ashgate.
Bartlomiej Swiatczak & Maria Rescigno (2012). How the Interplay Between Antigen Presenting Cells and Microbiota Tunes Host Immune Responses in the Gut. Seminars in Immunology 24 (1):43-49.
David L. Hull, Rodney E. Langman & Sigrid S. Glenn (2001). A General Account of Selection: Biology, Immunology, and Behavior. Behavioral and Brain Sciences 24 (3):511-528.
Niall Shanks (2001). Modeling Biological Systems: The Belousov–Zhabotinsky Reaction. [REVIEW] Foundations of Chemistry 3 (1):33-53.
Amin Turki (2011). On the Normativity of the Immune System. Medicine Studies 3 (1):29-39.
Eileen Crist & Alfred I. Tauber (2000). Selfhood, Immunity, and the Biological Imagination: The Thought of Frank MacFarlane Burnet. [REVIEW] Biology and Philosophy 15 (4):509-533.
Thomas Pradeu (2012). The Limits of the Self: Immunology and Biological Identity. Oxford University Press.
Thomas Pradeu & Edgardo D. Carosella (2006). The Self Model and the Conception of Biological Identity in Immunology. Biology and Philosophy 21 (2):235-252.
Added to index2009-01-28
Total downloads20 ( #70,275 of 1,004,651 )
Recent downloads (6 months)1 ( #64,617 of 1,004,651 )
How can I increase my downloads?