Abstract
The philosophy of a science has arisen as a result of inability of the theory of knowledge to reply to important questions which were rised before scientific community on a boundary of the XIX and XX centuries. Further the philosophy of a science and the theory of knowledge developed separately from each other. They had a big influence on each other, but their tasks were always different. The main distinction between them epistemology is a theoretical and projective kind of knowledge while philosophy of a science – post theoretical discipline. Epistemology is the theory including an explanatory scheme, it is a philosophical project of knowledge, and it is the discipline containing a set of interdictions and instructions. The philosophy of a science is interested in studying of scientific knowledge as a real event, which went through, making an expert estimation of results. The philosophy of a science assumes critical and reflective comparison of the project and result whereas the theory of knowledge improves specifications and discipline of cognitive activity. While the theory of knowledge creates a methodand is guided by a method the philosophy of a science prefers a historical and critical reflection, the logical-grammatical analysis, searches of cultural or social determination.