Mutated mtDNA distribution in exponentially growing cell cultures and how the segregation rate is increased by the mitochondrial compartments
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 49 (4):235-245 (2001)
A cell contains many copies of mitochondrial DNA. The distribution of a mitochondrial gene mutation in a cell culture is governed by the way in which the mtDNA molecules of a cell are replicated and partitioned between the two daughter cells during mitosis. Assuming that this partition process is random, we describe the evolution of the mitochondrial genetic state of a cell culture. The mutated mtDNA is ultimately segregated and the rate of the trend to segregation is relatively slow. It is nevertheless greatly accelerated if the model takes into account the spatial mtDNA partition by the mitochondrial compartments.
|Keywords||Philosophy Philosophy of Biology Evolutionary Biology|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Imre Szebik (1999). Response to “Germ Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation” by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman (CQ Vol 4, No 3) Altering the Mitochondrial Genome: Is It Just a Technical Issue? [REVIEW] Cambridge Quarterly of Healthcare Ethics 8 (3):369-374.
Peter D. Sozou & Thomas B. L. Kirkwood, A Stochastic Model of Cell Replicative Senescence Based on Telomere Shortening, Oxidative Stress, and Somatic Mutations in Nuclear and Mitochondrial DNA.
Joachim W. Ellwart & Peter Dörmer (1992). Measurement of Efflux From G1-Phase in a Growth Factor Dependent Cell Line. Acta Biotheoretica 40 (2-3):139-146.
Nicolas Rasmussen (1995). Mitochondrial Structure and the Practice of Cell Biology in the 1950s. Journal of the History of Biology 28 (3):381 - 429.
Philippe Tracqui & Jacques Ohayon (2004). Transmission of Mechanical Stresses Within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model. Acta Biotheoretica 52 (4):323-341.
François Guillaud & Patrick Hannaert (2008). Dynamic Simulation of Mitochondrial Respiration and Oxidative Phosphorylation: Comparison with Experimental Results. Acta Biotheoretica 56 (1-2):157-172.
Melinda B. Fagan (2011). Social Experiments in Stem Cell Biology. Perspectives on Science 19 (3):235-262.
William Bechtel (2007). In Search of Mitochondrial Mechanisms: Interfield Excursions Between Cell Biology and Biochemistry. Journal of the History of Biology 40 (1):1 - 33.
Gerd Richter & Matthew D. Bacchetta (1998). Interventions in the Human Genome: Some Moral and Ethical Considerations. Journal of Medicine and Philosophy 23 (3):303 – 317.
Added to index2009-01-28
Total downloads4 ( #391,339 of 1,707,813 )
Recent downloads (6 months)4 ( #160,268 of 1,707,813 )
How can I increase my downloads?