Ephestia: The Experimental Design of Alfred Kühn's Physiological Developmental Genetics [Book Review]
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Journal of the History of Biology 33 (3):535 - 576 (2000)
Much of the early history of developmental and physiological genetics in Germany remains to be written. Together with Carl Correns and Richard Goldschmidt, Alfred Kühn occupies a special place in this history. Trained as a zoologist in Freiburg im Breisgau, he set out to integrate physiology, development and genetics in a particular experimental system based on the flour moth Ephestia kühniella Zeller. This paper is meant to reconstruct the crucial steps in the experimental pathway that led Kühn and his collaborators at the University of Göttingen, and later at the Kaiser Wilhelm Institutes of Biology and Biochemistry in Berlin, to formulate, in their specific way, what later became known as the "one gene-one enzyme hypothesis." Special attention will be given to the interaction of the different parts of Kühn's Ephestia-based project, which were rooted in different research traditions. The paper retraces how, roughly between 1925 and 1945, these elements came to form a mixed experimental setup composed of genetic, embryological, physiological and, finally, biochemical constituents. Accordingly, emphasis is laid on the development of the terminology in which the results were cast, and how it reflected the hybrid state of an experimental system successively acquiring new epistemic layers.
|Keywords||Alfred Kühn Ernst Caspari Ephestia kühniella physiological developmental genetics one gene – one enzyme hypothesis gene action chains eye pigment formation tissue transplantation|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
Gerald L. Geison & Manfred D. Laubichler (2001). The Varied Lives of Organisms: Variation in the Historiography of the Biological Sciences. Studies in History and Philosophy of Science Part C 32 (1):1-29.
U. Deichmann (2002). Emigration, Isolation and the Slow Start of Molecular Biology in Germany. Studies in History and Philosophy of Science Part C 33 (3):449-471.
Marsha L. Richmond (2007). Muriel Wheldale Onslow and Early Biochemical Genetics. Journal of the History of Biology 40 (3):389 - 426.
Robert Meunier (2012). Stages in the Development of a Model Organism as a Platform for Mechanistic Models in Developmental Biology: Zebrafish, 1970–2000. Studies in History and Philosophy of Science Part C 43 (2):522-531.
María Jesús Santesmases (forthcoming). The Bacterial Cell Wall in the Antibiotic Era: An Ontology in Transit Between Morphology and Metabolism, 1940s–1960s. Journal of the History of Biology.
Similar books and articles
Hans-Jörg Rheinberger (2010). An Epistemology of the Concrete: Twentieth-Century Histories of Life. Duke University Press.
U. Deichmann (2011). Early 20th-Century Research at the Interfaces of Genetics, Development, and Evolution: Reflections on Progress and Dead Ends. Developmental Biology 357 (1):3-12.
Marcel Weber (2011). Experimentation Versus Theory Choice: A Social-Epistemological Approach. In Hans Bernhard Schmid, Daniel Sirtes & Marcel Weber (eds.), Collective Epistemology. Ontos 20--203.
Garland E. Allen (1974). Opposition to the Mendelian-Chromosome Theory: The Physiological and Developmental Genetics of Richard Goldschmidt. [REVIEW] Journal of the History of Biology 7 (1):49 - 92.
Christophe Bonneuil (2006). Mendelism, Plant Breeding and Experimental Cultures: Agriculture and the Development of Genetics in France. [REVIEW] Journal of the History of Biology 39 (2):281 - 308.
Alan Baker (2008). Experimental Mathematics. Erkenntnis 68 (3):331 - 344.
A. Cunningham (2002). The Pen and the Sword: Recovering the Disciplinary Identity of Physiology and Anatomy Before 1800 - I: Old Physiology-the Pen. Studies in History and Philosophy of Science Part C 33 (4):631-665.
Joseph Rouse (2013). Recovering Thomas Kuhn. Topoi 32 (1):59-64.
Peter J. Beurton, Raphael Falk & Hans-Jörg Rheinberger (eds.) (2000). The Concept of the Gene in Development and Evolution: Historical and Epistemological Perspectives. Cambridge University Press.
Jan Sprenger (2009). Evidence and Experimental Design in Sequential Trials. Philosophy of Science 76 (5):637-649.
Steindór J. Erlingsson (2009). The Plymouth Laboratory and the Institutionalization of Experimental Zoology in Britain in the 1920s. Journal of the History of Biology 42 (1):151 - 183.
Bojana Mladenović (2007). "Muckraking in History": The Role of the History of Science in Kuhn's Philosophy. Perspectives on Science 15 (3):261-294.
Hans-Jorg Rheinberger (1997). Experimental Complexity in Biology: Some Epistemological and Historical Remarks. Philosophy of Science 64 (4):254.
Maureen O'Malley & Karola Stotz (2011). Intervention, Integration and Translation in Obesity Research: Genetic, Developmental and Metaorganismal Approaches. Philosophy, Ethics, and Humanities in Medicine 6 (1):2-.
Maureen O'Malley & Karola Stotz (2011). Intervention, Integration and Translation in Obesity Research: Genetic, Developmental and Metaorganismal Approaches. Philosophy, Ethics, and Humanities in Medicine 6 (1):1-14.
Added to index2011-05-29
Total downloads10 ( #235,035 of 1,726,249 )
Recent downloads (6 months)1 ( #369,877 of 1,726,249 )
How can I increase my downloads?