David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Journal of Medicine and Philosophy 23 (3):303 – 317 (1998)
In the debate regarding the different possibilities for gene therapy, it is presupposed that the manipulations are limited to the nuclear genome (nDNA). Given recent advances in genetics, mitochondrial genome (mtDNA) and diseases must be considered as well. In this paper, we propose a three dimensional framework for the ethical debate of gene therapy where we add the genomic type (nDNA vs. mtDNA) as a third dimension to be considered beside the paradigmatic dimensions of target cell (somatic vs. germ-line) and purpose (therapeutic vs. enhancement). Somatic gene therapy can be viewed today as generally accepted, and we review t he contemporary arguments surrounding it on the basis of bioethical-pragmatic, socio-political and deontological classifications. Many of the supposed ethical questions of somatic gene therapy today are not new; they are well-known issues of research ethics. We also critically summarize the different international perspectives and the German ethical discussion regarding manipulations of germ-line cells.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Ray Moseley (1991). Commentary: Maintaining the Somatic/Germ-Line Distinction: Some Ethical Drawbacks. Journal of Medicine and Philosophy 16 (6):641-647.
Torbjörn Tännsjö (1993). Should We Change the Human Genome? Theoretical Medicine and Bioethics 14 (3).
W. French Anderson (1989). Human Gene Therapy: Why Draw a Line? Journal of Medicine and Philosophy 14 (6):681-693.
W. French Anderson (1985). Human Gene Therapy: Scientific and Ethical Considerations. Journal of Medicine and Philosophy 10 (3):275-292.
John C. Fletcher (1985). Ethical Issues in and Beyond Prospective Clinical Trials of Human Gene Therapy. Journal of Medicine and Philosophy 10 (3):293-310.
Bernard M. Gert (1991). Genetic Disorders and the Ethical Status of Germ-Line Gene Therapy. Journal of Medicine and Philosophy 16 (6):667-683.
Gregory Fowler, Eric T. Juengst & Burke K. Zimmerman (1989). Germ-Line Gene Therapy and the Clinical Ethos of Medical Genetics. Theoretical Medicine and Bioethics 10 (2).
Maurizio Salvi (2001). Shaping Individuality: Human Inheritable Germ Line Gene Modification. Theoretical Medicine and Bioethics 22 (6):527-542.
Isaac Rabino (2003). Gene Therapy: Ethical Issues. Theoretical Medicine and Bioethics 24 (1):31-58.
Added to index2009-01-28
Total downloads14 ( #113,572 of 1,100,778 )
Recent downloads (6 months)6 ( #44,058 of 1,100,778 )
How can I increase my downloads?