David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jonathan Jenkins Ichikawa
Jack Alan Reynolds
Learn more about PhilPapers
History and Philosophy of the Life Sciences 26 (1):59 - 80 (2004)
Recent work on gene concepts has been influenced by recognition of the extent to which RNA transcripts from a given DNA sequence yield different products in different cellular environments. These transcripts are altered in many ways and yield many products based, somehow, on the sequence of nucleotides in the DNA. I focus on alternative splicing of RNA transcripts (which often yields distinct proteins from the same raw transcript) and on 'gene sharing', in which a single gene produces distinct proteins with the exact same amino acid sequence. These are instances of molecular pleiotropy, in which distinct molecules are derived from a single putative gene. In such cases the cellular and external environments play major roles in determining which protein is produced. Where there is molecular pleiotropy, alternative gene concepts are naturally deployed; molecular epigenesis (revision of sequence-based information by altering molecular conformations or by action of non-informational molecules) plays a major role in orderly development. These results show that gene concepts in molecular biology do, and should, have both structural and functional components. They also show the need for a plurality of gene concepts and reveal fundamental difficulties in stabilizing gene concepts solely by reference to nucleotide sequence
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
Paul E. Griffiths & Karola Stotz (2006). Genes in the Postgenomic Era. Theoretical Medicine and Bioethics 27 (6):499-521.
Ingo Brigandt (2010). The Epistemic Goal of a Concept: Accounting for the Rationality of Semantic Change and Variation. Synthese 177 (1):19-40.
Karola Stotz & Paul Griffiths (2016). Epigenetics: Ambiguities and Implications. History and Philosophy of the Life Sciences 38 (4).
Paul E. Griffiths & Karola Stotz (2008). Experimental Philosophy of Science. Philosophy Compass 3 (3):507–521.
Tudor M. Baetu (2012). Genes After the Human Genome Project. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 43 (1):191-201.
Similar books and articles
Jeffrey H. Schwartz & Bruno Maresca (2006). Do Molecular Clocks Run at All? A Critique of Molecular Systematics. Biological Theory 1 (4):357-371.
Baljinder Sahdra & Paul Thagard (2003). Procedural Knowledge in Molecular Biology. Philosophical Psychology 16 (4):477 – 498.
Joel B. Hagen (1999). Naturalists, Molecular Biologists, and the Challenges of Molecular Evolution. Journal of the History of Biology 32 (2):321 - 341.
Davide Pisani, Michael J. Benton & Mark Wilkinson (2007). Congruence of Morphological and Molecular Phylogenies. Acta Biotheoretica 55 (3):269-281.
John R. Jungck (1982). Is the Neo-Darwinian Synthesis Robust Enough to Withstand the Challenge of Recent Discoveries in Molecular Biology and Molecular Evolution? PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1982:322 - 328.
Thomas Fogle (1990). Are Genes Units of Inheritance? Biology and Philosophy 5 (3):349-371.
Robert Bishop (2005). Patching Physics and Chemistry Together. Philosophy of Science 72 (5):710-722.
Robert C. Bishop (2005). Patching Physics and Chemistry Together. Philosophy of Science 72 (5):710-722.
Lenny Moss (2006). The Question of Questions: What is a Gene? Comments on Rolston and Griffths & Stotz. [REVIEW] Theoretical Medicine and Bioethics 27 (6):523-534.
C. Kenneth Waters (1994). Genes Made Molecular. Philosophy of Science 61 (2):163-185.
Added to index2010-08-10
Total downloads14 ( #314,367 of 1,941,080 )
Recent downloads (6 months)2 ( #334,045 of 1,941,080 )
How can I increase my downloads?