David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Nature Genetics 37 (4):441-444 (2005)
The primary impediment to formulating a general theory for adaptive evolution has been the unknown distribution of fitness effects for new beneficial mutations. By applying extreme value theory, Gillespie circumvented this issue in his mutational landscape model for the adaptation of DNA sequences, and Orr recently extended Gillespie's model, generating testable predictions regarding the course of adaptive evolution. Here we provide the first empirical examination of this model, using a single-stranded DNA bacteriophage related to phiX174, and find that our data are consistent with Orr's predictions, provided that the model is adjusted to incorporate mutation bias. Orr's work suggests that there may be generalities in adaptive molecular evolution that transcend the biological details of a system, but we show that for the model to be useful as a predictive or inferential tool, some adjustments for the biology of the system will be necessary.
|Keywords||Evolution Experimental Bacteriophage|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
William Harper, Sheldon J. Chow & Gemma Murray (2012). Bayesian Chance. Synthese 186 (2):447-474.
Similar books and articles
Charles H. Smith (1986). A Contribution to the Geographical Interpretation of Biological Change. Acta Biotheoretica 35 (4):229-278.
Leigh Van Valen (2009). How Ubiquitous is Adaptation? A Critique of the Epiphenomenist Program. Biology and Philosophy 24 (2):267-280.
Lev Yampolsky & Arlin Stoltzfus (2001). Bias in the Introduction of Variation as an Orienting Factor in Evolution. Evolution and Development 3 (2):73-83.
Jeff Kirby (2003). A New Group-Selection Model for the Evolution of Homosexuality. Biology and Philosophy 18 (5):683-694.
Gregory J. Morgan (2001). Bacteriophage Biology and Kenneth Schaffner's Rendition of Developmentalism. Biology and Philosophy 16 (1):85-92.
Arlin Stoltzfus & Lev Yampolsky (2009). Climbing Mount Probable: Mutation as a Cause of Non-Randomness in Evolution. Journal of Heredity 100 (5):637-647.
Added to index2009-12-02
Total downloads17 ( #147,710 of 1,699,835 )
Recent downloads (6 months)1 ( #362,609 of 1,699,835 )
How can I increase my downloads?