David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 49 (4):291-300 (2001)
Stimulation of airway myocytes by contractile agents such as acetylcholine (ACh) activates a Ca2+-activated Cl– current (IClCa) which may play a key role in calcium homeostasis of airway myocytes and hence in airway reactivity. The aim of the present study was to model IClCa in airway smooth muscle cells using a computerised model previously designed for simulation of cardiac myocyte functioning. Modelling was based on a simple resistor-battery permeation model combined with multiple binding site activation by calcium. In order to validate the model, a combination of equations, used to mimic [Ca2+]i response to ACh stimulation, were incorporated into the model. The results indicate that the model developed in this article accounts for experimental recordings and electrophysiological characteristics of this current in airway smooth muscle cells, with parameter values consistent with those calculated from experimental data. Such a model may thus be used to predict IClCa functioning, though additional experimental data from airway myocytes would be useful to more accurately determine some parameter values of the model.
|Keywords||Philosophy Philosophy of Biology Evolutionary Biology|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Scott Moss & Bruce Edmonds (1994). Modelling Learning as Modelling. Philosophical Explorations.
Audrey Pustoc'H., Jacques Ohayon, Yves Usson, Alain Kamgoue & Philippe Tracqui (2005). An Integrative Model of the Self-Sustained Oscillating Contractions of Cardiac Myocytes. Acta Biotheoretica 53 (4):277-293.
B. M. P. M. Oliveira (2010). Dynamics of Immunological Models. Acta Biotheoretica 58 (4):391-404.
Andrzej Kasperski (2008). Modelling of Cells Bioenergetics. Acta Biotheoretica 56 (3):233-247.
A. Defontaine, A. Hernández & G. Carrault (2004). Multi-Formalism Modelling and Simulation: Application to Cardiac Modelling. Acta Biotheoretica 52 (4):273-290.
S. Khirani, L. Biot, P. Lavagne, A. Duguet, T. Similowski & P. Baconnier (2004). Identification of a Non-Linear Model as a New Method to Detect Expiratory Airflow Limitation in Mechanically Ventilated Patients. Acta Biotheoretica 52 (4):241-254.
Larry A. Taber (2000). Pattern Formation in a Nonlinear Membrane Model for Epithelial Morphogenesis. Acta Biotheoretica 48 (1):47-63.
Paco Lorente, Carmen Delgado, Mario Delmar & Jose Jalife (1992). Analytical Modeling of the Hysteresis Phenomenon in Guinea Pig Ventricular Myocytes. Acta Biotheoretica 40 (2-3):177-193.
Added to index2009-01-28
Total downloads8 ( #381,178 of 1,792,850 )
Recent downloads (6 months)4 ( #207,535 of 1,792,850 )
How can I increase my downloads?