On the Possibility of Directed Mutations in Bacteria: Statistical Analyses and Reductionist Strategies
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1990:111 - 124 (1990)
The ongoing controversy about the possibility of directed mutations in bacteria is examined for its methodological, and thereby philosophical, implications. The method of fluctuation analysis, widely used to investigate whether mutations are random or directed, is described and subjected to a conceptual critique which shows that it cannot decide whether some mutations are directed while most are random. In this context, recent experiments that exploit this possibility to suggest that directed mutations occur in bacteria are described. Interpretive and experimental responses to such claims are briefly analyzed. Finally it is argued that mere statistical analysis, such as fluctuation analysis, cannot resolve this dispute. What will probably be required is an investigation of mechanisms of mutagenesis, an investigation that is intrinsically reductive.
|Keywords||No keywords specified (fix it)|
No categories specified
(categorize this paper)
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
J. T. Manning & D. J. Thompson (1984). Muller's Ratchet and the Accumulation of Favourable Mutations. Acta Biotheoretica 33 (4).
Janine Guespin-Michel & Marcelle Kaufman (2001). Positive Feedback Circuits and Adaptive Regulations in Bacteria. Acta Biotheoretica 49 (4).
Marcel Weber (1996). Evolutionary Plasticity in Prokaryotes: A Panglossian View. Biology and Philosophy 11 (1):67-88.
I. Walker (1996). Prediction of Evolution? Somatic Plasticity as a Basic, Physiological Condition for the Viability of Genetic Mutations. Acta Biotheoretica 44 (2).
Michael Bölker (2004). Bear Ye One Another's Genetic Burdens: The Price of Diversity and Complexity. Poiesis and Praxis 3 (s 1-2):73-82.
Michael B.�Lker (2004). Bear Ye One Another?S Genetic Burdens: The Price of Diversity and Complexity. Poiesis and Praxis 3 (1-2):73-82.
Francesca Merlin (2010). Evolutionary Chance Mutation: A Defense of the Modern Synthesis' Consensus View. Philosophy and Theory in Biology 2 (20130604).
Masatoshi Nei (2007). The New Mutation Theory of Phenotypic Evolution. Proc Natl Acad Sci U S A 104 (30):12335-12242.
Werner Ehm (2005). Meta-Analysis O Mind-Matter Experiments: A Statistical Modeling Perspective. Mind and Matter 3 (1):85-132.
R. P. Farrell & C. A. Hooker (2009). Error, Error-Statistics and Self-Directed Anticipative Learning. Foundations of Science 14 (4):249-271.
Steven W. Gangestad & Ronald A. Yeo (2006). Mutations, Developmental Instability, and the Red Queen. Behavioral and Brain Sciences 29 (4):412-413.
Robert Schwartz (1996). Directed Perception. Philosophical Psychology 9 (1):81-91.
J. T. Manning & D. P. E. Dickson (1986). Environmental Change, Mutational Load and the Advantage of Sexual Reproduction. Acta Biotheoretica 35 (3).
Sorry, there are not enough data points to plot this chart.
Added to index2011-05-29
Recent downloads (6 months)0
How can I increase my downloads?