Underconstrained thalamic activation + underconstrained top-down modulation of cortical input processing = underconstrained perceptions

Behavioral and Brain Sciences 27 (6):803-804 (2004)
Abstract
Behrendt & Young's (B&Y's) theory offers a potentially important perspective on the neurobiology of schizophrenia, but it remains incomplete. In addition to bottom-up contributions, such as those associated with disturbances in sensory constraints on cognitive processes, a comprehensive model requires the integration of the consequences of abnormal top-down modulation of input processing for the evolution of “underconstrained” perceptions. Dysfunctional cholinergic modulation of input functions represents a necessary mechanism for the generation of false perceptions.
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