David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 54 (1):13-19 (2006)
We propose a discrete time branching process to model the appearance of drug resistance under treatment. Under our assumptions at every discrete time a pathogen may die with probability 1−p or divide in two with probability p. Each newborn pathogen is drug resistant with probability μ. We start with N drug sensitive pathogens and with no drug resistant pathogens. We declare the treatment successful if all pathogens are eradicated before drug resistance appears. The model predicts that success is possible only if p<1/2. Even in this case the probability of success decreases exponentially with the parameter m=μN. In particular, even with a very potent drug (i.e. p very small) drug resistance is likely if m is large.
|Keywords||Philosophy Philosophy of Biology Evolutionary Biology|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Zbigniew Szawarski (2004). The Concept of Placebo. Science and Engineering Ethics 10 (1):57-64.
Kristin R. Swanson, Ellsworth C. Alvord & J. D. Murray (2002). Quantifying Efficacy of Chemotherapy of Brain Tumors with Homogeneous and Heterogeneous Drug Delivery. Acta Biotheoretica 50 (4):223-237.
Peter R. Mansfield (2005). Banning All Drug Promotion is the Best Option Pending Major Reforms. Journal of Bioethical Inquiry 2 (2):75-81.
Michael J. Selgelid (2007). Ethics and Drug Resistance. Bioethics 21 (4):218–229.
Nancy F. Olivieri (2003). Patients' Health or Company Profits? The Commercialisation of Academic Research. Science and Engineering Ethics 9 (1):29-41.
Michael Huemer (2004). America's Unjust Drug War. In Bill Masters (ed.), The New Prohibition. Accurate Press
Hugh LaFollette (1994). Mandatory Drug Testing. In Steven Luper & C. Brown (eds.), Drugs, Morality, and the Law. Garland
William C. Buhles (2011). Compassionate Use A Story of Ethics and Science in the Development of a New Drug. Perspectives in Biology and Medicine 54 (3):304-315.
Added to index2009-01-28
Total downloads7 ( #291,659 of 1,724,890 )
Recent downloads (6 months)3 ( #210,935 of 1,724,890 )
How can I increase my downloads?