David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
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Behavioral and Brain Sciences 20 (4):597-614 (1997)
Long-term potentiation (LTP) is operationally defined as a long-lasting increase in synaptic efficacy following high-frequency stimulation of afferent fibers. Since the first full description of the phenomenon in 1973, exploration of the mechanisms underlying LTP induction has been one of the most active areas of research in neuroscience. Of principal interest to those who study LTP, particularly in the mammalian hippocampus, is its presumed role in the establishment of stable memories, a role consistent with descriptions of memory formation. Other characteristics of LTP, including its rapid induction, persistence, and correlation with natural brain rhythms, provide circumstantial support for this connection to memory storage. Nonetheless, there is little empirical evidence that directly links LTP to the storage of memories. In this target article we review a range of cellular and behavioral characteristics of LTP and evaluate whether they are consistent with the purported role of hippocampal LTP in memory formation. We suggest that much of the present focus on LTP reflects a preconception that LTP is a learning mechanism, although the empirical evidence often suggests that LTP is unsuitable for such a role. As an alternative to serving as a memory storage device, we propose that LTP may serve as a neural equivalent to an arousal or attention device in the brain. Accordingly, LTP may increase in a nonspecific way the effective salience of discrete external stimuli and may thereby facilitate the induction of memories at distant synapses. Other hypotheses regarding the functional utility of this intensely studied mechanism are conceivable; the intent of this target article is not to promote a single hypothesis but rather to stimulate discussion about the neural mechanisms underlying memory storage and to appraise whether LTP can be considered a viable candidate for such a mechanism
|Keywords||arousal attention calcium classical conditioning Hebbian synapses hippocampus memory systems NMDA spatial learning synaptic plasticity theta rhythm|
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Citations of this work BETA
John Bickle (2006). Reducing Mind to Molecular Pathways: Explicating the Reductionism Implicit in Current Cellular and Molecular Neuroscience. [REVIEW] Synthese 151 (3):411-434.
Maurice K. D. Schouten & Huib Looren De Jong (1999). Reduction, Elimination, and Levels: The Case of the LTP-Learning Link. Philosophical Psychology 12 (3):237 – 262.
Huib L. de Jong & Maurice K. D. Schouten (2005). Ruthless Reductionism: A Review Essay of John Bickle's Philosophy and Neuroscience: A Ruthlessly Reductive Account. [REVIEW] Philosophical Psychology 18 (4):473-486.
Huib Looren de Jong & Maurice K. D. Schouten (2005). Ruthless Reductionism: A Review Essay of John Bickle's Philosophy and Neuroscience: A Ruthlessly Reductive Account. Philosophical Psychology 18 (4):473-486.
Huib L. de Jong (2006). Explicating Pluralism: Where the Mind to Molecule Pathway Gets Off the Track - Reply to Bickle. Synthese 151 (3):435-443.
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