Graduate studies at Western
Foundations of Chemistry 8 (1):3-29 (2006)
|Abstract||Enzymes are protein catalysts of extraordinary efficiency, capable of bringing about rate enhancements of their biochemical reactions that can approach factors of 1020. Theories of enzyme catalysis, which seek to explain the means by which enzymes effect catalytic transformation of the substrate molecules on which they work, have evolved over the past century from the “lock-and-key” model proposed by Emil Fischer in 1894 to models that explicitly rely on transition state theory to the most recent theories that strive to provide accounts that stress the essential role of protein dynamics. In this paper, I attempt to construct a metaphysical framework within which these new models of enzyme catalysis can be developed. This framework is constructed from key doctrines of process thought, which gives ontologic priority to becoming over being, as well as tenets of a process philosophy of chemistry, which stresses environmentally responsive molecular transformation. Enzyme catalysis can now be seen not as enzyme acting on its substrate, but rather as enzyme and substrate entering into a relation which allows them to traverse the reaction coordinate as an ontologic unity.|
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
J. Prideaux (2011). Kinetic Models of (M-R)-Systems. Axiomathes 21 (3):373-392.
Ray Paton & Koichiro Matsuno (1998). Some Common Themes for Enzymes and Verbs. Acta Biotheoretica 46 (2).
Lois Isenman (2009). Trusting Your Gut, Among Other Things: Digestive Enzyme Secretion, Intuition, and the History of Science. [REVIEW] Foundations of Science 14 (4):315-329.
S. Schnell & C. Mendoza (2001). A Fast Method to Estimate Kinetic Constants for Enzyme Inhibitors. Acta Biotheoretica 49 (2).
I. Walker (1979). The Mechanical Properties of Proteins Determine the Laws of Evolutionary Change. Acta Biotheoretica 28 (4).
Robert Costalat (1996). Enzyme Organization and Stability of Metabolic Pathways: A Comparison of Various Approaches. Acta Biotheoretica 44 (3-4).
Lois Isenman (2009). Digestive Enzyme Secretion, Intuition, and the History of Science: Part II. [REVIEW] Foundations of Science 14 (4):331-349.
Harvey J. Gold (1971). Proton Tunneling and Enzyme Catalysis. Acta Biotheoretica 20 (1-2).
Pedro Mendes & Douglas B. Kell (1993). On the Role of Enzyme Kinetic Parameters in Determining the Effectiveness with Which Channelling Can Decrease the Size of a Metabolite Pool. Acta Biotheoretica 41 (1-2).
Added to index2009-01-28
Total downloads11 ( #107,775 of 756,673 )
Recent downloads (6 months)1 ( #63,427 of 756,673 )
How can I increase my downloads?