David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Foundations of Chemistry 8 (1):3-29 (2006)
Enzymes are protein catalysts of extraordinary efficiency, capable of bringing about rate enhancements of their biochemical reactions that can approach factors of 1020. Theories of enzyme catalysis, which seek to explain the means by which enzymes effect catalytic transformation of the substrate molecules on which they work, have evolved over the past century from the “lock-and-key” model proposed by Emil Fischer in 1894 to models that explicitly rely on transition state theory to the most recent theories that strive to provide accounts that stress the essential role of protein dynamics. In this paper, I attempt to construct a metaphysical framework within which these new models of enzyme catalysis can be developed. This framework is constructed from key doctrines of process thought, which gives ontologic priority to becoming over being, as well as tenets of a process philosophy of chemistry, which stresses environmentally responsive molecular transformation. Enzyme catalysis can now be seen not as enzyme acting on its substrate, but rather as enzyme and substrate entering into a relation which allows them to traverse the reaction coordinate as an ontologic unity.
|Keywords||Philosophy History Philosophy of Science Physical Chemistry Chemistry/Food Science, general|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
David Ray Griffin (ed.) (1988). The Reenchantment of Science: Postmodern Proposals. State University of New York Press.
Nicholas Rescher (2000). Process Philosophy: A Survey of Basic Issues. University of Pittsburgh Press.
Ivor Leclerc (1972). The Nature of Physical Existence. New York,Humanities Press.
Mario Bunge (1971). Is Scientific Metaphysics Possible? Journal of Philosophy 68 (17):507-520.
Citations of this work BETA
Ross L. Stein (2006). An Inquiry Into the Origins of Life on Earth- a Synthesis of Process Thought in Science and Theology. Zygon 41 (4):995-1016.
Similar books and articles
J. Prideaux (2011). Kinetic Models of (M-R)-Systems. Axiomathes 21 (3):373-392.
Ray Paton & Koichiro Matsuno (1998). Some Common Themes for Enzymes and Verbs. Acta Biotheoretica 46 (2):131-140.
Lois Isenman (2009). Trusting Your Gut, Among Other Things: Digestive Enzyme Secretion, Intuition, and the History of Science. [REVIEW] Foundations of Science 14 (4):315-329.
S. Schnell & C. Mendoza (2001). A Fast Method to Estimate Kinetic Constants for Enzyme Inhibitors. Acta Biotheoretica 49 (2):109-113.
I. Walker (1979). The Mechanical Properties of Proteins Determine the Laws of Evolutionary Change. Acta Biotheoretica 28 (4):239-282.
Robert Costalat (1996). Enzyme Organization and Stability of Metabolic Pathways: A Comparison of Various Approaches. Acta Biotheoretica 44 (3-4):235-247.
Lois Isenman (2009). Digestive Enzyme Secretion, Intuition, and the History of Science: Part II. [REVIEW] Foundations of Science 14 (4):331-349.
Harvey J. Gold (1971). Proton Tunneling and Enzyme Catalysis. Acta Biotheoretica 20 (1-2):29-40.
Pedro Mendes & Douglas B. Kell (1993). On the Role of Enzyme Kinetic Parameters in Determining the Effectiveness with Which Channelling Can Decrease the Size of a Metabolite Pool. Acta Biotheoretica 41 (1-2):63-73.
Added to index2009-01-28
Total downloads19 ( #147,771 of 1,726,249 )
Recent downloads (6 months)4 ( #183,615 of 1,726,249 )
How can I increase my downloads?