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- Daniel Steel, Extrapolation, Capacities, and Mechanisms.(Chapter 5 of Across the Boundaries, forthcoming, from Oxford University Press) This chapter argues that previous accounts of extrapolation, either by reference to capacities or mechanisms, do not adequately address the challenges confronting extrapolation. It then begins the account of how the mechanisms-approach can be developed so as to do better. The central concept in this account is what I term comparative process tracing.No categories
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Any account of extrapolation from animal models to humans must confront two basic challenges: explain how extrapolation can be justified even when there are causally relevant differences between model and target, and explain how the suitability of a model can be established given only limited information about the target. We argue that existing approaches to extrapolation—either in terms of capacities or mechanisms—do not adequately address these challenges. However, we propose a further elaboration of the mechanisms approach that provides a better (...)
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