Acta Biotheoretica 44 (2) (1996)
|Abstract||A hypothesis of genome structural evolution is explored. Rapid and cohesive alterations in genome organization are viewed as resulting from the dynamic and constrained interactions of chromosomal subsystem components. A combination of macromolecular boundary conditions and DNA element involvement in far-from-equilibrium reactions is proposed to increase the complexity of genomic subsystems via the channelling of genome turnover; interactions between subsystems create higher-order subsystems expanding the phase space for further genetic evolution. The operation of generic constraints on structuration in genome evolution is suggested by i) universal, homoplasic features of chromosome organization and ii) the metastable nature of genome structures where lower-level flux is constrained by higher-order structures. Phenomena such as genomic shock, bursts of transposable element activity, concerted evolution, etc., are hypothesized to result from constrained systemic responses to endogenous/exogenous, micro/macro perturbations. The constraints operating on genome turnover are expected to increase with chromosomal structural complexity, the number of interacting subsystems, and the degree to which interactions between genomic components are tightly ordered.|
|Keywords||No keywords specified (fix it)|
|Through your library||Configure|
Similar books and articles
Paul E. Griffiths & Karola Stotz (2006). Genes in the Postgenomic Era. Theoretical Medicine and Bioethics 27 (6):499-521.
Ehud Lamm (2010). Review Of: Julian Huxley, Evolution: The Modern Synthesis – The Definitive Edition. [REVIEW] Integrative Psychological and Behavioral Science.
Ehud Lamm (2011). The Metastable Genome: A Lamarckian Organ in a Darwinian World? In Eva Jablonka & Snait Gissis (eds.), Transformations of Lamarckism: from subtle fluids to molecular biology. MIT Press.
Gunther Witzany, The Viral Origins of Telomeres and Telomerases and Their Important Role in Eukaryogenesis and Genome Maintenance.
John A. Robertson (2003). The $1000 Genome: Ethical and Legal Issues in Whole Genome Sequencing of Individuals. American Journal of Bioethics 3 (3):35-42.
Günther Witzany (2006). Natural Genome-Editing Competences of Viruses. Acta Biotheoretica 54 (4).
Alexander E. Vinogradov (2001). Mirrored Genome Size Distributions in Monocot and Dicot Plants. Acta Biotheoretica 49 (1).
Ehud Lamm (2010). Genes Versus Genomes: The Role of Genome Organization in Evolution. Dissertation, Tel Aviv University
Added to index2009-01-28
Total downloads4 ( #178,748 of 549,122 )
Recent downloads (6 months)1 ( #63,361 of 549,122 )
How can I increase my downloads?