David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Journal of Heredity 100 (5):637-647 (2009)
The classic view of evolution as "shifting gene frequencies" in the Modern Synthesis literally means that evolution is the modulation of existing variation ("standing variation"), as opposed to a "new mutations" view of evolution as a 2-step process of mutational origin followed by acceptance-or-rejection (via selection and drift). The latter view has received renewed attention, yet its implications for evolutionary causation still are not widely understood. We review theoretical results showing that this conception of evolution allows for a role of mutation as a cause of nonrandomness, a role that could be important but has been misconceived and associated misleadingly with neutral evolution. Specifically, biases in the introduction of variation, including mutational biases, may impose predictable biases on evolution, with no necessary dependence on neutrality. As an example of how important such effects may be, we present a new analysis partitioning the variance in mean rates of amino acid replacement during human-chimpanzee divergence to components of codon mutation and amino acid exchangeability. The results indicate that mutational effects are not merely important but account for most of the variance explained. The challenge that such results pose for comparative genomics is to address mutational effects as a necessary part of any analysis of causal factors. To meet this challenge requires developing knowledge of mutation as a biological process, understanding how mutation imposes propensities on evolution, and applying methods of analysis that incorporate mutational effects.
|Keywords||evolutionary theory population genetics mutation mutation bias|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
Arlin Stoltzfus & Kele Cable (2014). Mendelian-Mutationism: The Forgotten Evolutionary Synthesis. Journal of the History of Biology 47 (4):501-546.
Iñigo Martincorena & Nicholas M. Luscombe (2013). Non‐Random Mutation: The Evolution of Targeted Hypermutation and Hypomutation. Bioessays 35 (2):123-130.
Similar books and articles
Hans Joachim Poethke (1988). Sex Ratio Polymorphism: The Impact of Mutation and Drift on Evolution. Acta Biotheoretica 37 (2):121-147.
Roberta L. Millstein & Robert A. Skipper (2007). Population Genetics. In David L. Hull & Michael Ruse (eds.), The Cambridge Companion to the Philosophy of Biology. Cambridge University Press
David M. Buss (2006). The Evolutionary Genetics of Personality: Does Mutation Load Signal Relationship Load? Behavioral and Brain Sciences 29 (4):409-409.
Matthew C. Keller & Geoffrey Miller (2006). Resolving the Paradox of Common, Harmful, Heritable Mental Disorders: Which Evolutionary Genetic Models Work Best? Behavioral and Brain Sciences 29 (4):385-404.
D. R. Rokyta, P. Joyce, S. B. Caudle & H. A. Wichman (2005). An Empirical Test of the Mutational Landscape Model of Adaptation Using a Single-Stranded DNA Virus. Nature Genetics 37 (4):441-444.
Masatoshi Nei (2007). The New Mutation Theory of Phenotypic Evolution. Proc Natl Acad Sci U S A 104 (30):12335-12242.
Andrew Buchanan & Mark A. Bedau, The Flexible Balance of Evolutionary Novelty and Memory in the Face of Environmental Catastrophes.
Arlin Stoltzfus (2006). Mutationism and the Dual Causation of Evolutionary Change. Evolution and Development 8 (3):304-317.
Lev Yampolsky & Arlin Stoltzfus (2001). Bias in the Introduction of Variation as an Orienting Factor in Evolution. Evolution and Development 3 (2):73-83.
Added to index2009-12-02
Total downloads18 ( #172,982 of 1,778,182 )
Recent downloads (6 months)1 ( #291,352 of 1,778,182 )
How can I increase my downloads?