The Impact of Gene–Environment Interaction and Correlation on the Interpretation of Heritability

Acta Biotheoretica (forthcoming)
Abstract
Abstract   The presence of gene–environment statistical interaction ( G x E ) and correlation ( rGE ) in biological development has led both practitioners and philosophers of science to question the legitimacy of heritability estimates. The paper offers a novel approach to assess the impact of G x E and rGE on the way genetic and environmental causation can be partitioned. A probabilistic framework is developed, based on a quantitative genetic model that incorporates G x E and rGE , offering a rigorous way of interpreting heritability estimates. Specifically, given an estimate of heritability and the variance components associated with estimates of G x E and rGE , I arrive at a probabilistic account of the relative effect of genes and environment. Content Type Journal Article Category Regular Article Pages 1-13 DOI 10.1007/s10441-011-9139-8 Authors Omri Tal, School of Philosophy and The Cohn Institute for the History and Philosophy of Science and Ideas, Tel Aviv University, Tel Aviv, 69978 Israel Journal Acta Biotheoretica Online ISSN 1572-8358 Print ISSN 0001-5342.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Options
 Save to my reading list
Follow the author(s)
My bibliography
Export citation
Find it on Scholar
Edit this record
Mark as duplicate
Revision history Request removal from index Translate to english
 
Download options
PhilPapers Archive


Upload a copy of this paper     Check publisher's policy on self-archival     Papers currently archived: 10,316
External links
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library
References found in this work BETA

No references found.

Citations of this work BETA

No citations found.

Similar books and articles
Omri Tal (2009). From Heritability to Probability. Biology and Philosophy 24 (1):81-105.
Neven Sesardic (1993). Heritability and Causality. Philosophy of Science 60 (3):396-418.
David Haig (2012). The Strategic Gene. Biology and Philosophy 27 (4):461-479.
Gry Oftedal (2005). Heritability and Genetic Causation. Philosophy of Science 72 (5):699-709.
Neven Sesardic (2003). Heritability and Indirect Causation. Philosophy of Science 70 (5):1002-1014.
Samir Okasha (2003). The Concept of Group Heritability. Biology and Philosophy 18 (3):445-461.
Analytics

Monthly downloads

Added to index

2011-08-27

Total downloads

13 ( #114,313 of 1,096,467 )

Recent downloads (6 months)

3 ( #90,211 of 1,096,467 )

How can I increase my downloads?

My notes
Sign in to use this feature


Discussion
Start a new thread
Order:
There  are no threads in this forum
Nothing in this forum yet.