David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 60 (3):225-237 (2012)
The presence of gene–environment statistical interaction and correlation in biological development has led both practitioners and philosophers of science to question the legitimacy of heritability estimates. The paper offers a novel approach to assess the impact of GxE and rGE on the way genetic and environmental causation can be partitioned. A probabilistic framework is developed, based on a quantitative genetic model that incorporates GxE and rGE, offering a rigorous way of interpreting heritability estimates. Specifically, given an estimate of heritability and the variance components associated with estimates of GxE and rGE, I arrive at a probabilistic account of the relative effect of genes and environment
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Omri Tal (2009). From Heritability to Probability. Biology and Philosophy 24 (1):81-105.
Neven Sesardic (1993). Heritability and Causality. Philosophy of Science 60 (3):396-418.
Peter J. Taylor (2012). A Gene-Free Formulation of Classical Quantitative Genetics Used to Examine Results and Interpretations Under Three Standard Assumptions. Acta Biotheoretica 60 (4):357-378.
Sidney J. Segalowitz (1999). Why Twin Studies Really Don't Tell Us Much About Human Heritability. Behavioral and Brain Sciences 22 (5):904-905.
David Haig (2012). The Strategic Gene. Biology and Philosophy 27 (4):461-479.
Gry Oftedal (2005). Heritability and Genetic Causation. Philosophy of Science 72 (5):699-709.
Sabina Leonelli (2012). Karen-Sue Taussig: Ordinary Genomes: Science, Citizenship and Genetic Identities. [REVIEW] Acta Biotheoretica 60 (3):319-322.
Peter Taylor (2006). Heritability and Heterogeneity: The Limited Relevance of Heritability in Investigating Genetic and Environmental Factors. Biological Theory 1 (2):150-164.
James Tabery (2009). From a Genetic Predisposition to an Interactive Predisposition: Rethinking the Ethical Implications of Screening for Gene-Environment Interactions. Journal of Medicine and Philosophy 34 (1):27-48.
Tudor Baetu (2012). Defining Species: A Multi-Level Approach. Acta Biotheoretica 60 (3):239-255.
Thomas Reydon (2011). Fritz Allhoff: Philosophies of the Sciences: A Guide. Acta Biotheoretica 59 (3):319-325.
Neven Sesardic (2003). Heritability and Indirect Causation. Philosophy of Science 70 (5):1002-1014.
Samir Okasha (2003). The Concept of Group Heritability. Biology and Philosophy 18 (3):445-461.
Raphael Scholl (2012). Did Darwin Write the Origin Backwards? Philosophical Essays on Darwin’s Theory. [REVIEW] Acta Biotheoretica 60 (3):323-328.
Fred Gifford (1989). Complex Genetic Causation of Human Disease: Critiques of and Rationales for Heritability and Path Analysis. Theoretical Medicine and Bioethics 10 (2).
Added to index2011-08-27
Total downloads13 ( #141,570 of 1,692,606 )
Recent downloads (6 months)1 ( #181,402 of 1,692,606 )
How can I increase my downloads?