David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
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Philosophy of Science 75 (2):224-245 (2008)
In biology, the ‘ecological orientation' rests on a commitment to examining systems, and the conceptual challenge of defining that system now employs techniques and concepts adapted from diverse disciplines (i.e., systems philosophy, cybernetics, information theory, computer science) that are applied to biological simulations and model building. Immunology has joined these efforts, and the question posed here is whether the discipline will remain committed to its theoretical concerns framed by the notions of protecting an insular self, an entity demarcated from its environment, or will shift its focus of interest to a wider context. An ecological perspective emphasizes the interchange between the organism and its environment, the processing of information, and the regulation arising from responses to this larger context. Moving from the first attempts at modeling the immune system as a closed network, immunologists have joined the general interest in systems analysis, and that move might portend a significant shift to an open, more holistic consideration of immune regulation. *Received December 2006; revised August 2007. †To contact the author, please write to: Center for Philosophy and History of Science, Boston University, 745 Commonwealth Ave., Boston, MA 02215; e-mail: email@example.com.
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References found in this work BETA
W. Ross Ashby (1956). An Introduction to Cybernetics. New York, J. Wiley.
Eileen Crist & Alfred I. Tauber (2000). Selfhood, Immunity, and the Biological Imagination: The Thought of Frank MacFarlane Burnet. [REVIEW] Biology and Philosophy 15 (4):509-533.
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Citations of this work BETA
Michelle Jamieson (2010). Imagining 'Reactivity': Allergy Within the History of Immunology. Studies in History and Philosophy of Science Part C 41 (4):356-366.
Bartlomiej Swiatczak (2013). Immune Balance: The Development of the Idea and its Applications. [REVIEW] Journal of the History of Biology:1-32.
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