David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
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Philosophy of Science 70 (2):235-254 (2003)
A biochemical pathway is a sequence of chemical reactions in a biological organism. Such pathways specify mechanisms that explain how cells carry out their major functions by means of molecules and reactions that produce regular changes. Many diseases can be explained by defects in pathways, and new treatments often involve finding drugs that correct those defects. This paper presents explanation schemas and treatment strategies that characterize how thinking about pathways contributes to biomedical discovery. It discusses the significance of pathways for understanding the nature of diseases, explanations, and theories.
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William Bechtel (2011). Mechanism and Biological Explanation. Philosophy of Science 78 (4):533-557.
William Bechtel & Adele A. Abrahamsen (2013). Thinking Dynamically About Biological Mechanisms: Networks of Coupled Oscillators. [REVIEW] Foundations of Science 18 (4):707-723.
Cory D. Wright (2012). Mechanistic Explanation Without the Ontic Conception. European Journal of Philosophy of Science 2 (3):375-394.
William Bechtel (2009). Looking Down, Around, and Up: Mechanistic Explanation in Psychology. Philosophical Psychology 22 (5):543-564.
Jonathan Y. Tsou (2012). Intervention, Causal Reasoning, and the Neurobiology of Mental Disorders: Pharmacological Drugs as Experimental Instruments. Studies in History and Philosophy of Science Part C 43 (2):542-551.
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